Disease relevance of LARGE

• The LARGE glycosyltransferase is mutated in both the myodystrophy mouse and congenital muscular dystrophy type 1D (MDC1D) [1].
• CONCLUSIONS: Large idiopathic chronic pericardial effusion is well tolerated for long periods in most patients, but severe tamponade can develop unexpectedly at any time [2].
• BACKGROUND: Large outbreaks of diarrhea caused by a newly recognized strain of Clostridium difficile occurred in four hospitals located in different parts of the United States between 1989 and 1992 [3].
• CONCLUSIONS: Large LDL size was an independent predictor of coronary events in a typical population with myocardial infarction, but the adverse effect was not present among patients who were treated with pravastatin [4].
• CONTEXT: Large-scale studies are needed to determine if cancers other than Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer occur in excess in persons with human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS) [5].

Psychiatry related information on LARGE

• Mutations in the human LARGE gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan [6].
• SETTING: Large, urban pediatric academic medical center in the northeastern United States. PARTICIPANTS: One hundred ninety children and adolescents (aged 8-17 years) hospitalized for traffic-related injury.Main Outcome Measure Clinician-Administered PTSD Scale for Children and Adolescents [7].
• The Large group displayed diffuse impairment, but were the only group to exhibit risky decision making [8].
• CONCLUSIONS: Large trials are uncommon in mental health [9].
• CONCLUSIONS: Large scale behavioral risk reduction appears to be occurring in this population regardless of treatment condition [10].

High impact information on LARGE

• GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large [11].
• We have investigated changes in the processing and function of alpha-DG resulting from genetic manipulation of LARGE, the putative glycosyltransferase mutated both in Large(myd) mice and in humans with congenital muscular dystrophy 1D (MDC1D) [12].
• STUDY SELECTION: Large blinded, prospective studies (having > or =300 patients with sore throat) reporting history and physical examination data and using throat culture as the reference standard were included [13].
• SETTING: Large health maintenance organization in northern California. PATIENTS: Women aged 15 to 59 years serotested for rubella during 1990 with continuous health plan membership for 2 years before and after the date of their serological test [14].
• The diverse functions of the brain are mediated by neurons and glia whose phenotype is defined by a dynamically maintained set of gene transcripts, or 'transcriptome'. Large-scale analysis of gene expression in postmortem brain using microarray technology has the potential to elucidate molecular changes that occur in disease states [15].

Chemical compound and disease context of LARGE

• Crystal Structure of 3-Hydroxybenzoate Hydroxylase from Comamonas testosteroni Has a Large Tunnel for Substrate and Oxygen Access to the Active Site [16].
• Article Title: A Prospective, Randomized, Comparison of Adrenaline Injection in Combination with Detachable Snare Versus Adrenaline Injection Alone in the Prevention of Post-polypectomy Bleeding in Large Colonic Polyps (Am J Gastroenterol 2006;101:2913) [17].
• CONCLUSIONS: Large doses (> or = 40 ml) of chloroprocaine containing EDTA resulted in a greater incidence of deep burning lumbar back pain [18].
• MATERIALS AND METHODS: Large-scale gene-expression profiling was performed during curcumin-triggered apoptosis (8-36 hours) in follicular lymphoma HF4.9 cells using Sentrix Human WG-6 BeadChips [19].
• CONCLUSIONS: Large colonic lipomas can be removed safely by electrosurgical snare resection after injection of the base with epinephrine or saline solution [20].

Biological context of LARGE

• Membrane turnover in outer segments of Rana pipiens red rods (ROS) was studied in tadpoles maintained under cyclic lighting (12L:12D) at 23 degrees, 28 degrees, and 33 degrees C. Large fragments (greater than 2 microns in diameter or length) were shed from the ROS tips shortly after the onset of light [21].
• Sixteen Y-chromosomal microsatellites and 16 binary markers have been used to analyze DNA variation in 408 male subjects from 15 populations in Central Asia. Large genetic differences were found between populations, but these did not display an obvious geographical or linguistic pattern like that usually seen for Y-chromosomal variation [22].
• BACKGROUND: Large-scale partial sequencing of cDNA libraries to generate expressed sequence tags (ESTs) is an effective means of discovering novel genes and characterizing transcription patterns in different tissues [23].
• CONCLUSION: Large cumulative doses of cyclophosphamide and chlorambucil were associated with the development of MDS, the occurrence of abnormalities of chromosome 5 and/or chromosome 7 deletions, and a poor prognosis [24].
• The Ancestral Distance Test: What Relatedness can Reveal about Correlated Evolution in Large Lineages with Missing Character Data and Incomplete Phylogenies [25].

Anatomical context of LARGE

• CONCLUSIONS: Large numbers of CD45RO-positive (activated memory but noncytotoxic) T cells as well as a predominant nuclear staining pattern for CSF-1 are associated with a poor outcome in breast cancer patients [26].
• BACKGROUND: Large pleural effusions sometimes occur after coronary artery bypass grafting (CABG), but their characteristics and clinical course are largely unknown [27].
• However, when the proton gradient is large 1) there is a passive leak of protons (and other ions) across these membranes, and 2) some proton pumps may fail to pump protons (a phenomenon known as slip) [28].
• High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer [29].
• PURPOSE: Large skull-base meningiomas are difficult to treat due to their proximity or adherence to critical structures [30].

Associations of LARGE with chemical compounds

• Hydrophobic Interface between Two Regulators of K+ Conductance Domains Critical for Calcium-dependent Activation of Large Conductance Ca2+-activated K+ Channels [31].
• RESULTS: Large locomotor deficits (increased hip flexion, decreased excursions of the knee and ankle, smaller extensor and flexor moments of force at the 3 joints, and muscle activation levels lower in all muscles tested) are still present in patients, particularly in the single-limb support subphase before and 2 months after TKA [32].
• The hemodynamic, local, and systemic tolerance of IAP, with or without cisplatin, was evaluated in Large White pigs [33].
• A Large Protonated Water Cluster H(+)(H(2)O)(27) in a 3D Metal-Organic Framework [34].
• Our data consisted of alignments from the European Ribosomal RNA Database of Bacterial and Eukaryotic Small Subunit and Large Subunit Ribosomal RNA ( Wuyts et al. 2001. Nucleic Acids Res. 29:175-177; Wuyts et al. 2002. Nucleic Acids Res. 30:183-185) [35].

Regulatory relationships of LARGE

• RECENT FINDINGS: Large case-control studies as well as cohort studies have demonstrated that cigarette smoking is a risk factor for RF positive and anti-citrulline antibody with rheumatoid arthritis and that the risk diminishes only several years after cessation of smoking [36].

Other interactions of LARGE

• We investigated the association of CCKAR polymorphisms with feeding, growth, and efficiency traits in an F(2) population derived from a cross between Meishan and Large White founder animals and in lines of Large White pigs that had been divergently selected on the basis of lean growth efficiency traits [37].
• CONCLUSION: Large-scale screening for HH can be performed at a relatively low cost if combined with a health survey programme [38].
• RESULTS: Large interindividual differences in TNF production were observed [39].
• Expression of Cytochromes P450 3A and P-Glycoprotein in Human Large Intestinse in Paired Tumour and Normal Samples [40].
• Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the Safety and Efficacy Large-scale Evaluation of COX-inhibiting Therapies (SELECT) trial in osteoarthritis [41].

Analytical, diagnostic and therapeutic context of LARGE

• DESIGN: Cohort study based on immunization records collected in the Pediatric Immunization Program. Setting Large public housing development in Chicago, Ill. PARTICIPANTS: All 1143 children who were born between 1991 and 1997 and enrolled between 1993 and mid-1998, with follow-up to age 35 months [42].
• CONCLUSIONS: Large numbers of ductal cells can be collected by ductal lavage to detect atypical cellular changes within the breast [43].
• METHODS: Large unilamellar vesicles containing trapped 3H inulin were prepared by extrusion and gel filtration [44].
• STUDY SELECTION: Large recent multicenter studies and the guidelines for early management of patients with acute myocardial infarction (American College of Cardiology/American Heart Association Task Force) were emphasized [45].
• BACKGROUND: Large, randomized, and blinded clinical trials (EPIC, EPILOG, and CAPTURE) have demonstrated that abciximab (ReoPro, chimeric 7E3 Fab) markedly reduces thrombotic events associated with percutaneous transluminal coronary interventions [46].

References