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Gene Review

LARGE  -  like-glycosyltransferase

Homo sapiens

Synonyms: Acetylglucosaminyltransferase-like 1A, Glycosyltransferase-like protein LARGE1, KIAA0609, LARGE1, MDC1D, ...
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Disease relevance of LARGE


Psychiatry related information on LARGE


High impact information on LARGE

  • GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large [11].
  • We have investigated changes in the processing and function of alpha-DG resulting from genetic manipulation of LARGE, the putative glycosyltransferase mutated both in Large(myd) mice and in humans with congenital muscular dystrophy 1D (MDC1D) [12].
  • STUDY SELECTION: Large blinded, prospective studies (having > or =300 patients with sore throat) reporting history and physical examination data and using throat culture as the reference standard were included [13].
  • SETTING: Large health maintenance organization in northern California. PATIENTS: Women aged 15 to 59 years serotested for rubella during 1990 with continuous health plan membership for 2 years before and after the date of their serological test [14].
  • The diverse functions of the brain are mediated by neurons and glia whose phenotype is defined by a dynamically maintained set of gene transcripts, or 'transcriptome'. Large-scale analysis of gene expression in postmortem brain using microarray technology has the potential to elucidate molecular changes that occur in disease states [15].

Chemical compound and disease context of LARGE


Biological context of LARGE

  • Membrane turnover in outer segments of Rana pipiens red rods (ROS) was studied in tadpoles maintained under cyclic lighting (12L:12D) at 23 degrees, 28 degrees, and 33 degrees C. Large fragments (greater than 2 microns in diameter or length) were shed from the ROS tips shortly after the onset of light [21].
  • Sixteen Y-chromosomal microsatellites and 16 binary markers have been used to analyze DNA variation in 408 male subjects from 15 populations in Central Asia. Large genetic differences were found between populations, but these did not display an obvious geographical or linguistic pattern like that usually seen for Y-chromosomal variation [22].
  • BACKGROUND: Large-scale partial sequencing of cDNA libraries to generate expressed sequence tags (ESTs) is an effective means of discovering novel genes and characterizing transcription patterns in different tissues [23].
  • CONCLUSION: Large cumulative doses of cyclophosphamide and chlorambucil were associated with the development of MDS, the occurrence of abnormalities of chromosome 5 and/or chromosome 7 deletions, and a poor prognosis [24].
  • The Ancestral Distance Test: What Relatedness can Reveal about Correlated Evolution in Large Lineages with Missing Character Data and Incomplete Phylogenies [25].

Anatomical context of LARGE


Associations of LARGE with chemical compounds

  • Hydrophobic Interface between Two Regulators of K+ Conductance Domains Critical for Calcium-dependent Activation of Large Conductance Ca2+-activated K+ Channels [31].
  • RESULTS: Large locomotor deficits (increased hip flexion, decreased excursions of the knee and ankle, smaller extensor and flexor moments of force at the 3 joints, and muscle activation levels lower in all muscles tested) are still present in patients, particularly in the single-limb support subphase before and 2 months after TKA [32].
  • The hemodynamic, local, and systemic tolerance of IAP, with or without cisplatin, was evaluated in Large White pigs [33].
  • A Large Protonated Water Cluster H(+)(H(2)O)(27) in a 3D Metal-Organic Framework [34].
  • Our data consisted of alignments from the European Ribosomal RNA Database of Bacterial and Eukaryotic Small Subunit and Large Subunit Ribosomal RNA ( Wuyts et al. 2001. Nucleic Acids Res. 29:175-177; Wuyts et al. 2002. Nucleic Acids Res. 30:183-185) [35].

Regulatory relationships of LARGE

  • RECENT FINDINGS: Large case-control studies as well as cohort studies have demonstrated that cigarette smoking is a risk factor for RF positive and anti-citrulline antibody with rheumatoid arthritis and that the risk diminishes only several years after cessation of smoking [36].

Other interactions of LARGE

  • We investigated the association of CCKAR polymorphisms with feeding, growth, and efficiency traits in an F(2) population derived from a cross between Meishan and Large White founder animals and in lines of Large White pigs that had been divergently selected on the basis of lean growth efficiency traits [37].
  • CONCLUSION: Large-scale screening for HH can be performed at a relatively low cost if combined with a health survey programme [38].
  • RESULTS: Large interindividual differences in TNF production were observed [39].
  • Expression of Cytochromes P450 3A and P-Glycoprotein in Human Large Intestinse in Paired Tumour and Normal Samples [40].
  • Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the Safety and Efficacy Large-scale Evaluation of COX-inhibiting Therapies (SELECT) trial in osteoarthritis [41].

Analytical, diagnostic and therapeutic context of LARGE

  • DESIGN: Cohort study based on immunization records collected in the Pediatric Immunization Program. Setting Large public housing development in Chicago, Ill. PARTICIPANTS: All 1143 children who were born between 1991 and 1997 and enrolled between 1993 and mid-1998, with follow-up to age 35 months [42].
  • CONCLUSIONS: Large numbers of ductal cells can be collected by ductal lavage to detect atypical cellular changes within the breast [43].
  • METHODS: Large unilamellar vesicles containing trapped 3H inulin were prepared by extrusion and gel filtration [44].
  • STUDY SELECTION: Large recent multicenter studies and the guidelines for early management of patients with acute myocardial infarction (American College of Cardiology/American Heart Association Task Force) were emphasized [45].
  • BACKGROUND: Large, randomized, and blinded clinical trials (EPIC, EPILOG, and CAPTURE) have demonstrated that abciximab (ReoPro, chimeric 7E3 Fab) markedly reduces thrombotic events associated with percutaneous transluminal coronary interventions [46].


  1. Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy. Brockington, M., Torelli, S., Prandini, P., Boito, C., Dolatshad, N.F., Longman, C., Brown, S.C., Muntoni, F. Hum. Mol. Genet. (2005) [Pubmed]
  2. Long-term follow-up of idiopathic chronic pericardial effusion. Sagristà-Sauleda, J., Angel, J., Permanyer-Miralda, G., Soler-Soler, J. N. Engl. J. Med. (1999) [Pubmed]
  3. Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals. Johnson, S., Samore, M.H., Farrow, K.A., Killgore, G.E., Tenover, F.C., Lyras, D., Rood, J.I., DeGirolami, P., Baltch, A.L., Rafferty, M.E., Pear, S.M., Gerding, D.N. N. Engl. J. Med. (1999) [Pubmed]
  4. Low-density lipoprotein size, pravastatin treatment, and coronary events. Campos, H., Moye, L.A., Glasser, S.P., Stampfer, M.J., Sacks, F.M. JAMA (2001) [Pubmed]
  5. Association of cancer with AIDS-related immunosuppression in adults. Frisch, M., Biggar, R.J., Engels, E.A., Goedert, J.J. JAMA (2001) [Pubmed]
  6. Mutations in the human LARGE gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Longman, C., Brockington, M., Torelli, S., Jimenez-Mallebrera, C., Kennedy, C., Khalil, N., Feng, L., Saran, R.K., Voit, T., Merlini, L., Sewry, C.A., Brown, S.C., Muntoni, F. Hum. Mol. Genet. (2003) [Pubmed]
  7. Heart rate and posttraumatic stress in injured children. Kassam-Adams, N., Garcia-España, J.F., Fein, J.A., Winston, F.K. Arch. Gen. Psychiatry (2005) [Pubmed]
  8. Decision-making processes following damage to the prefrontal cortex. Manes, F., Sahakian, B., Clark, L., Rogers, R., Antoun, N., Aitken, M., Robbins, T. Brain (2002) [Pubmed]
  9. Comparison of large versus smaller randomized trials for mental health-related interventions. Contopoulos-Ioannidis, D.G., Gilbody, S.M., Trikalinos, T.A., Churchill, R., Wahlbeck, K., Ioannidis, J.P. The American journal of psychiatry. (2005) [Pubmed]
  10. Changes in HIV risk behavior among injecting drug users: the impact of 21 versus 90 days of methadone detoxification. Iguchi, M.Y., Bux, D.A., Lidz, V., French, J.F., Baxter, R.C., Platt, J.J. AIDS (1996) [Pubmed]
  11. GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large. Beutler, B., Jiang, Z., Georgel, P., Crozat, K., Croker, B., Rutschmann, S., Du, X., Hoebe, K. Annu. Rev. Immunol. (2006) [Pubmed]
  12. LARGE can functionally bypass alpha-dystroglycan glycosylation defects in distinct congenital muscular dystrophies. Barresi, R., Michele, D.E., Kanagawa, M., Harper, H.A., Dovico, S.A., Satz, J.S., Moore, S.A., Zhang, W., Schachter, H., Dumanski, J.P., Cohn, R.D., Nishino, I., Campbell, K.P. Nat. Med. (2004) [Pubmed]
  13. The rational clinical examination. Does this patient have strep throat? Ebell, M.H., Smith, M.A., Barry, H.C., Ives, K., Carey, M. JAMA (2000) [Pubmed]
  14. Risk of chronic arthropathy among women after rubella vaccination. Vaccine Safety Datalink Team. Ray, P., Black, S., Shinefield, H., Dillon, A., Schwalbe, J., Holmes, S., Hadler, S., Chen, R., Cochi, S., Wassilak, S. JAMA (1997) [Pubmed]
  15. Progress in the use of microarray technology to study the neurobiology of disease. Mirnics, K., Pevsner, J. Nat. Neurosci. (2004) [Pubmed]
  16. Crystal Structure of 3-Hydroxybenzoate Hydroxylase from Comamonas testosteroni Has a Large Tunnel for Substrate and Oxygen Access to the Active Site. Hiromoto, T., Fujiwara, S., Hosokawa, K., Yamaguchi, H. J. Mol. Biol. (2006) [Pubmed]
  17. Continuing medical education: december 2006. Scolapio, J.S., Al-Haddad, M. Am. J. Gastroenterol. (2006) [Pubmed]
  18. Back pain after epidural anesthesia with chloroprocaine. Stevens, R.A., Urmey, W.F., Urquhart, B.L., Kao, T.C. Anesthesiology (1993) [Pubmed]
  19. Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4. Skommer, J., Wlodkowic, D., Pelkonen, J. Exp. Hematol. (2007) [Pubmed]
  20. Endoscopic removal of large colonic lipomas. Kim, C.Y., Bandres, D., Tio, T.L., Benjamin, S.B., Al-Kawas, F.H. Gastrointest. Endosc. (2002) [Pubmed]
  21. Turnover of rod photoreceptor outer segments. I. Membrane addition and loss in relationship to temperature. Hollyfield, J.G., Besharse, J.C., Rayborn, M.E. J. Cell Biol. (1977) [Pubmed]
  22. A genetic landscape reshaped by recent events: Y-chromosomal insights into central Asia. Zerjal, T., Wells, R.S., Yuldasheva, N., Ruzibakiev, R., Tyler-Smith, C. Am. J. Hum. Genet. (2002) [Pubmed]
  23. A genome-based resource for molecular cardiovascular medicine: toward a compendium of cardiovascular genes. Hwang, D.M., Dempsey, A.A., Wang, R.X., Rezvani, M., Barrans, J.D., Dai, K.S., Wang, H.Y., Ma, H., Cukerman, E., Liu, Y.Q., Gu, J.R., Zhang, J.H., Tsui, S.K., Waye, M.M., Fung, K.P., Lee, C.Y., Liew, C.C. Circulation (1997) [Pubmed]
  24. Cytogenetic abnormalities and therapy-related myelodysplastic syndromes in rheumatic disease. McCarthy, C.J., Sheldon, S., Ross, C.W., McCune, W.J. Arthritis Rheum. (1998) [Pubmed]
  25. The Ancestral Distance Test: What Relatedness can Reveal about Correlated Evolution in Large Lineages with Missing Character Data and Incomplete Phylogenies. Hearn, D., Huber, M. Syst. Biol. (2006) [Pubmed]
  26. Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. Scholl, S.M., Pallud, C., Beuvon, F., Hacene, K., Stanley, E.R., Rohrschneider, L., Tang, R., Pouillart, P., Lidereau, R. J. Natl. Cancer Inst. (1994) [Pubmed]
  27. Large pleural effusions occurring after coronary artery bypass grafting. Cardiovascular Surgery Associates, PC. Light, R.W., Rogers, J.T., Cheng, D., Rodriguez, R.M. Ann. Intern. Med. (1999) [Pubmed]
  28. The leaks and slips of bioenergetic membranes. Brown, G.C. FASEB J. (1992) [Pubmed]
  29. High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer. Piersma, S.J., Jordanova, E.S., van Poelgeest, M.I., Kwappenberg, K.M., van der Hulst, J.M., Drijfhout, J.W., Melief, C.J., Kenter, G.G., Fleuren, G.J., Offringa, R., van der Burg, S.H. Cancer Res. (2007) [Pubmed]
  30. High efficacy of fractionated stereotactic radiotherapy of large base-of-skull meningiomas: long-term results. Debus, J., Wuendrich, M., Pirzkall, A., Hoess, A., Schlegel, W., Zuna, I., Engenhart-Cabillic, R., Wannenmacher, M. J. Clin. Oncol. (2001) [Pubmed]
  31. Hydrophobic Interface between Two Regulators of K+ Conductance Domains Critical for Calcium-dependent Activation of Large Conductance Ca2+-activated K+ Channels. Kim, H.J., Lim, H.H., Rho, S.H., Eom, S.H., Park, C.S. J. Biol. Chem. (2006) [Pubmed]
  32. Locomotor deficits before and two months after knee arthroplasty. Ouellet, D., Moffet, H. Arthritis Rheum. (2002) [Pubmed]
  33. High intra-abdominal pressure enhances the penetration and antitumor effect of intraperitoneal cisplatin on experimental peritoneal carcinomatosis. Esquis, P., Consolo, D., Magnin, G., Pointaire, P., Moretto, P., Ynsa, M.D., Beltramo, J.L., Drogoul, C., Simonet, M., Benoit, L., Rat, P., Chauffert, B. Ann. Surg. (2006) [Pubmed]
  34. A Large Protonated Water Cluster H(+)(H(2)O)(27) in a 3D Metal-Organic Framework. Wei, M., He, C., Hua, W., Duan, C., Li, S., Meng, Q. J. Am. Chem. Soc. (2006) [Pubmed]
  35. Empirical models for substitution in ribosomal RNA. Smith, A.D., Lui, T.W., Tillier, E.R. Mol. Biol. Evol. (2004) [Pubmed]
  36. Smoking as a trigger for inflammatory rheumatic diseases. Klareskog, L., Padyukov, L., Alfredsson, L. Current opinion in rheumatology (2007) [Pubmed]
  37. A polymorphism in the 5'-untranslated region of the porcine cholecystokinin type a receptor gene affects feed intake and growth. Houston, R.D., Haley, C.S., Archibald, A.L., Cameron, N.D., Plastow, G.S., Rance, K.A. Genetics (2006) [Pubmed]
  38. Screening for hemochromatosis: high prevalence and low morbidity in an unselected population of 65,238 persons. Asberg, A., Hveem, K., Thorstensen, K., Ellekjter, E., Kannelønning, K., Fjøsne, U., Halvorsen, T.B., Smethurst, H.B., Sagen, E., Bjerve, K.S. Scand. J. Gastroenterol. (2001) [Pubmed]
  39. Differences in the intrinsic capacity of peripheral blood mononuclear cells to produce tumor necrosis factor alpha and beta in patients with inflammatory bowel disease and healthy controls. Bouma, G., Oudkerk Pool, M., Scharenberg, J.G., Kolkman, J.J., von Blomberg, B.M., Scheper, R.J., Meuwissen, S.G., Peña, A.S. Scand. J. Gastroenterol. (1995) [Pubmed]
  40. Expression of Cytochromes P450 3A and P-Glycoprotein in Human Large Intestinse in Paired Tumour and Normal Samples. Canaparo, R., Nordmark, A., Finnström, N., Lundgren, S., Seidegård, J., Jeppsson, B., Edwards, R.J., Boobis, A.R., Rane, A. Basic Clin. Pharmacol. Toxicol. (2007) [Pubmed]
  41. Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the Safety and Efficacy Large-scale Evaluation of COX-inhibiting Therapies (SELECT) trial in osteoarthritis. Dequeker, J., Hawkey, C., Kahan, A., Steinbrück, K., Alegre, C., Baumelou, E., Bégaud, B., Isomäki, H., Littlejohn, G., Mau, J., Papazoglou, S. Br. J. Rheumatol. (1998) [Pubmed]
  42. Hepatitis B vaccination among children in inner-city public housing, 1991-1997. Lauderdale, D.S., Oram, R.J., Goldstein, K.P., Daum, R.S. JAMA (1999) [Pubmed]
  43. Ductal lavage for detection of cellular atypia in women at high risk for breast cancer. Dooley, W.C., Ljung, B.M., Veronesi, U., Cazzaniga, M., Elledge, R.M., O'Shaughnessy, J.A., Kuerer, H.M., Hung, D.T., Khan, S.A., Phillips, R.F., Ganz, P.A., Euhus, D.M., Esserman, L.J., Haffty, B.G., King, B.L., Kelley, M.C., Anderson, M.M., Schmit, P.J., Clark, R.R., Kass, F.C., Anderson, B.O., Troyan, S.L., Arias, R.D., Quiring, J.N., Love, S.M., Page, D.L., King, E.B. J. Natl. Cancer Inst. (2001) [Pubmed]
  44. Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts. Heuman, D.M., Bajaj, R. Gastroenterology (1994) [Pubmed]
  45. The role of risk stratification in the early management of a myocardial infarction. Krone, R.J. Ann. Intern. Med. (1992) [Pubmed]
  46. Abciximab (ReoPro, chimeric 7E3 Fab) demonstrates equivalent affinity and functional blockade of glycoprotein IIb/IIIa and alpha(v)beta3 integrins. Tam, S.H., Sassoli, P.M., Jordan, R.E., Nakada, M.T. Circulation (1998) [Pubmed]
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