Disease relevance of cheA

• Genome-wide transcriptional profiling in a histidine kinase mutant of Helicobacter pylori identifies members of a regulon [1].

High impact information on cheA

• We found that chemotaxis in the cheW Che+ suppressor depended on both cheY and cheA [2].
• This study demonstrates the importance of the roles of cheY1, cheY2, and cheA in motility and virulence of H. pylori [3].
• These results indicate that the signal transduction circuit utilizing HK0164 controls the transcription of at least seven genes in H. pylori [1].
• To identify putative members of a regulon controlled by the H. pylori sensory histidine kinase HP0164 (HK0164), we constructed HK0164 null mutant H. pylori strains and analyzed bacterial gene transcription using DNA arrays [1].
• Furthermore, we provide evidence that the variability of the histidine kinase HP165 caused by a poly(C) tract of variable length close to the 3' end of open reading frame 165/164 does not interfere with the kinase activity of the transmitter domain of HP165 [4].

Biological context of cheA

• An analysis of the in vitro phosphorylation properties of the two-component proteins demonstrates that HP244-HP703 and HP165-HP166 are cognate histidine kinase-response regulator pairs [4].

References