Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

MeSH Review:

Parechovirus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Parechovirus

Here, we demonstrate that the replication of parechovirus 1 (ParV1) is partly resistant to BFA, whereas echovirus 11 (EV11) replication is strongly inhibited [1].
To study humoral and cellular immunity against human parechovirus type 1 (HPEV1), the viral capsid proteins VP0, VP1, and VP3 were expressed and purified as glutathione S-transferase (GST)-tagged recombinant proteins [2].

High impact information on Parechovirus

These findings indicate that the parechovirus 2C protein has enzymatic activities, which may contribute to several functions in the viral replication cycle [3].
To define structural elements critical for RNA replication in human parechovirus 1 (HPeV1), a replicon with chloramphenicol acetyltransferase as a reporter gene and an infectious virus cDNA clone have been used [4].
In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus [5].
TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1 [5].

References

Differential requirements for COPI coats in formation of replication complexes among three genera of Picornaviridae. Gazina, E.V., Mackenzie, J.M., Gorrell, R.J., Anderson, D.A. J. Virol. (2002) [Pubmed]
Diagnostic potential of parechovirus capsid proteins. Alho, A., Marttila, J., Ilonen, J., Hyypiä, T. J. Clin. Microbiol. (2003) [Pubmed]
ATP hydrolysis and AMP kinase activities of nonstructural protein 2C of human parechovirus 1. Samuilova, O., Krogerus, C., Fabrichniy, I., Hyypiä, T. J. Virol. (2006) [Pubmed]
Terminal RNA replication elements in human parechovirus 1. Nateri, A.S., Hughes, P.J., Stanway, G. J. Virol. (2002) [Pubmed]
TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1. Triantafilou, K., Vakakis, E., Orthopoulos, G., Ahmed, M.A., Schumann, C., Lepper, P.M., Triantafilou, M. Eur. J. Immunol. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share