Disease relevance of Hedera

• In vitro activity of hederacolchisid A1 compared with other saponins from Hedera colchica against proliferation of human carcinoma and melanoma cells [1].
• Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.) [2].
• The anti-inflammatory potential of alpha-hederin (monodesmoside) and hederasaponin-C from Hedera helix, and hederacolchisides-E and -F (bidesmosides) from H. colchica was investigated in carrageenan-induced acute paw edema in rats [3].

High impact information on Hedera

• The woody plants Hedera and Aucuba translocated sucrose as the dominant sugar species, and only traces of RFOs [4].
• These antibodies also recognize a major band of similar size in developing seeds of English ivy (Hedera helix), an Araliaceae species that also accumulates petroselinic acid in a seed-specific manner [5].
• It has previously been demonstrated that hederacolchiside-A1 (HCol-A1), a triterpenoid saponin from Hedera colchica Koch, has antimelanoma potential [6].
• The antioxidant activities of alpha-hederin and hederasaponin-C from Hedera helix, and hederacolchisides-E and -F from Hedera colchica were investigated, in this study [7].
• Here we report the isolation and immunoaffinity purification of plant natriuretic peptide (PNP) from ivy (Hedera helix) with rabbit anti-alpha-ANP (1-28) (human, canine) antiserum [8].

Associations of Hedera with chemical compounds

• Hederacolchisid A1, a new oleanolic acid monodesmoside, isolated from Hedera colchica K [1].
• In a human maximization test of 5% falcarinol isolated from Hedera helix, 10 of 20 subjects were sensitized [9].
• Falcarinol and didehydrofalcarinol also occur in Hedera helix subsp. canariensis [2].
• Under these conditions, saponins in powdered dried leaves of Hedera helix were measured at a concentration of 21.83 mg/g for hederacoside C, 0.41 mg/g for alpha-hederin and 0.02 mg/g for hederagenin [10].
• Human maximization test of falcarinol, the principal contact allergen of English ivy and Algerian ivy (Hedera helix, H. canariensis) [9].

Gene context of Hedera

• Experimental and chemical investigations revealed that common ivy (Hedera helix susp. helix) contains 3 compounds which are powerful irritants and moderate sensitizers [2].

References