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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Hedera


High impact information on Hedera

  • The woody plants Hedera and Aucuba translocated sucrose as the dominant sugar species, and only traces of RFOs [4].
  • These antibodies also recognize a major band of similar size in developing seeds of English ivy (Hedera helix), an Araliaceae species that also accumulates petroselinic acid in a seed-specific manner [5].
  • It has previously been demonstrated that hederacolchiside-A1 (HCol-A1), a triterpenoid saponin from Hedera colchica Koch, has antimelanoma potential [6].
  • The antioxidant activities of alpha-hederin and hederasaponin-C from Hedera helix, and hederacolchisides-E and -F from Hedera colchica were investigated, in this study [7].
  • Here we report the isolation and immunoaffinity purification of plant natriuretic peptide (PNP) from ivy (Hedera helix) with rabbit anti-alpha-ANP (1-28) (human, canine) antiserum [8].

Associations of Hedera with chemical compounds


Gene context of Hedera

  • Experimental and chemical investigations revealed that common ivy (Hedera helix susp. helix) contains 3 compounds which are powerful irritants and moderate sensitizers [2].


  1. In vitro activity of hederacolchisid A1 compared with other saponins from Hedera colchica against proliferation of human carcinoma and melanoma cells. Barthomeuf, C., Debiton, E., Mshvildadze, V., Kemertelidze, E., Balansard, G. Planta Med. (2002) [Pubmed]
  2. Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.). Hausen, B.M., Bröhan, J., König, W.A., Faasch, H., Hahn, H., Bruhn, G. Contact Derm. (1987) [Pubmed]
  3. Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema. Gepdiremen, A., Mshvildadze, V., Süleyman, H., Elias, R. Phytomedicine (2005) [Pubmed]
  4. Ultrastructure of minor-vein phloem and assimilate export in summer and winter leaves of the symplasmically loading evergreens Ajuga reptans L., Aucuba japonica Thunb., and Hedera helix L. Hoffmann-Thoma, G., van Bel, A.J., Ehlers, K. Planta (2001) [Pubmed]
  5. An unusual seed-specific 3-ketoacyl-ACP synthase associated with the biosynthesis of petroselinic acid in coriander. Mekhedov, S., Cahoon, E.B., Ohlrogge, J. Plant Mol. Biol. (2001) [Pubmed]
  6. Inhibition of HUVEC tubulogenesis by hederacolchiside-A1 is associated with plasma membrane cholesterol sequestration and activation of the Ha-Ras/MEK/ERK cascade. Barthomeuf, C., Boivin, D., Béliveau, R. Cancer Chemother. Pharmacol. (2004) [Pubmed]
  7. Antioxidant activity of saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F. Gülçin, I., Mshvildadze, V., Gepdiremen, A., Elias, R. Planta Med. (2004) [Pubmed]
  8. Isolation and immunoaffinity purification of biologically active plant natriuretic peptide. Billington, T., Pharmawati, M., Gehring, C.A. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  9. Human maximization test of falcarinol, the principal contact allergen of English ivy and Algerian ivy (Hedera helix, H. canariensis). Gafner, F., Epstein, W., Reynolds, G., Rodriguez, E. Contact Derm. (1988) [Pubmed]
  10. An unusual case of death: suffocation caused by leaves of common ivy (Hedera helix). Detection of hederacoside C, alpha-hederin, and hederagenin by LC-EI/MS-MS. Gaillard, Y., Blaise, P., Darré, A., Barbier, T., Pépin, G. Journal of analytical toxicology. (2003) [Pubmed]
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