Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Drug Antagonism

Ohashi, M. et al., Barron, M.A. et al., Molinengo, L. et al.

Barron, Doyle, Zlotkin,

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High impact information on Drug Antagonism

Results indicated that eight of 26 patients (31%) were vitamin K deficient; four cases were attributed to drug antagonism (phenytoin) and four were due to inadequate vitamin K intake, synthesis or malabsorption [1].
Drug antagonism studied on frog flexor reflex and on mouse motility [2].
Curves of experimentally plotted log (dose ratio-1) vs.-log [B] for the antagonism between adrenergic beta-mimetics, isoproterenol (ISO) and trimetoquinol (TMQ), and various beta-antagonists in relaxation of guinea-pig trachea could not be reasonably fitted to Schild's equation which has been commonly used in the analysis of drug-antagonism [3].

References

Vitamin K deficiency in children pre-bone marrow transplantation. Barron, M.A., Doyle, J., Zlotkin, S. Bone Marrow Transplant. (2006) [Pubmed]
Drug antagonism studied on frog flexor reflex and on mouse motility. Molinengo, L., Orsetti, M. Pharmacology (1983) [Pubmed]
Studies on the mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (II). Analysis by the uptake saturation model. Ohashi, M., Iwasawa, Y., Kiyomoto, A. Jpn. J. Pharmacol. (1976) [Pubmed]

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