Disease relevance of Longevity

• BACKGROUND: In cystic fibrosis (CF) patients, lung transplantation is the only way to improve both quality and length of life [1].

High impact information on Longevity

• CONCLUSION: If it is confirmed that improvements in pathologic response rates with HDC effectively translate into increased probabilities of survival for IBC patients, adoption of such treatment as PEGASE 02 will not involve crucial choices between length of life and QOL and should not be delayed for QOL arguments [2].
• Glucose disposal efficiency and insulin response were associated with increased quality and length of life in diet-restricted dogs [3].
• There is ample evidence that treatment with levodopa improves the quality and length of life, and no real evidence that delaying therapy confers benefits in the future [4].
• BACKGROUND: Past studies have measured and described the length of life with disability before death, but there has been no study of the relationship between modifiable lifestyle factors and duration of disability [5].
• Further, QALYs have limited applicability here because, as a short term supportive treatment, epoetin enhances the quality but not the length of life [6].

Biological context of Longevity

• The major histocompatibility complex may be important in determining profiles of cause of death and length of life in mice [7].

Associations of Longevity with chemical compounds

• The 5-HIAA levels measured during the index admission correlated with the length of life after delirium suggesting that serotonergic dysfunction may have prognostic significance in delirious patients [8].
• The clinician's armamentarium is no longer limited to zidovudine as the only antiretroviral agent that enhances both quality and length of life. ddI has shown clinical benefit in patients previously treated with zidovudine [9].

Gene context of Longevity

• The AChE levels measured during the index admission correlated with the length of life after delirium, suggesting that cholinergic dysfunction may have prognostic significance in delirious patients [10].
• The median length of life of all VHL and non-VHL patients was 46 and 63 years, respectively [11].
• Rheumatoid arthritis reduces not only quality but also length of life [12].

References