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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Effect of gamma-glutamyl carboxylation of renal microsomes on calcium oxalate monohydrate crystal binding in hyperoxaluria.

AIM: The gamma-carboxy glutamic acid (gla) containing proteins have been shown recently to have a role in calcium oxalate urolithiasis. Therefore, the effect of carboxylation on calcium oxalate monohydrate (COM) binding was studied in experimental hyperoxaluria. METHODS: Urolithiasis was induced in experimental rats by oral feeding 1% ethylene glycol (EG). The microsomes were carboxylated in presence of reduced vitamin K and COM binding activity was determined. RESULTS: Microsomal proteins adsorbed maximally with COM crystals. On carboxylation of the renal microsomal proteins, a significant increase in the COM crystal adsorption by 2.5-fold (p < 0.001) was observed in the hyperoxaluric condition. Further cyboxylated microsomes of EG-treated rats showed significant binding with calcium oxalate. CONCLUSION: This study presents an increased COM adsorption after the carboxylation of renal microsomes of hyperoxaluric rats.[1]

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