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Rhode, H. et al.

Rhode, Lopatta, Schulze, Pascual, Schulze, Schubert, Schubert, Reinhart, Horn,

Glycosylphosphatidylinositol-specific phospholipase D in blood serum: is the liver the only source of the enzyme?

In cases of systemic inflammatory response syndrome, sepsis, and septic shock, the activity of glycosylphosphatidylinositol-specific phospholipase D ( GPI-PLD) in serum amounts to 20 to 25% of the activity found in a healthy control group. The activity of serum GPI-PLD is positively correlated with inflammatory markers and counts of monocytes and stab cells (bands) and negatively correlated with polymorphonuclear neutrophils and lymphocytes in severe diseases. This indicates a yet unknown involvement of the inflammatory system in GPI-PLD liberation and suggests that the liver is not the only source of the plasma enzyme. Plasma was shown to contain an effective inhibitor of GPI-PLD which is soluble in organic solvents. Its concentration in capillary plasma is 20-fold higher than in venous plasma. To find possible other sources of plasma GPI-PLD besides the liver, the GPI-degrading activity was measured in different organs of the rat. Product formation was analysed using [125I]TID-labeled GPI-AP.[1]

References

Glycosylphosphatidylinositol-specific phospholipase D in blood serum: is the liver the only source of the enzyme? Rhode, H., Lopatta, E., Schulze, M., Pascual, C., Schulze, H.P., Schubert, K., Schubert, H., Reinhart, K., Horn, A. Clin. Chim. Acta (1999) [Pubmed]

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