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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen.

In an effort to identify tumor-specific antigens recognized by CD4(+) T cells, an approach was developed that allows the screening of an invariant chain-complementary DNA fusion library in a genetically engineered cell line expressing the essential components of the major histocompatibility complex (MHC) class II processing and presentation pathway. This led to the identification of a mutated form of human CDC27, which gave rise to an HLA-DR4-restricted melanoma antigen. A mutated form of triosephosphate isomerase, isolated by a biochemical method, was also identified as an HLA-DR1-restricted antigen. Thus, this approach may be generally applicable to the identification of antigens recognized by CD4(+) T cells, which could aid the development of strategies for the treatment of patients with cancer, autoimmune diseases, or infectious diseases.[1]


  1. Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen. Wang, R.F., Wang, X., Atwood, A.C., Topalian, S.L., Rosenberg, S.A. Science (1999) [Pubmed]
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