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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cutting edge: expression of the NF of activated T cells in eosinophils: regulation by IL-4 and IL-5.

We report that NF-AT1 and NF-AT4 are expressed cytoplasmically in resting eosinophils, whereas NF-AT2 and NF-AT3 have not been seen. Likewise, NF-AT1 mRNA and NF-AT4 mRNA have been detected in resting eosinophils, and their levels can be significantly up-regulated by the Th2-associated cytokines IL-4 and IL-5. There is no detectable NF-AT protein expression in the nuclei of resting eosinophils. However NF-ATs appear in the nuclei of IL-4-, IL-5-, or ionomycin-stimulated eosinophils. Only NF-AT1 and NF-AT4, but not NF-AT2 and NF-AT3, have translocated into the nuclei in IL-4- or IL-5-stimulated eosinophils. These findings delineate a novel pathway in the cytokine network in which Th2 lymphocytes "control" eosinophils via the release of IL-4 and IL-5, and activation of NF-AT in eosinophils. The findings also suggest that a later feedback "talking" may exist between eosinophils and Th2 lymphocytes.[1]


  1. Cutting edge: expression of the NF of activated T cells in eosinophils: regulation by IL-4 and IL-5. Jinquan, T., Quan, S., Jacobi, H.H., Reimert, C.M., Millner, A., Hansen, J.B., Thygesen, C., Ryder, L.P., Madsen, H.O., Malling, H.J., Poulsen, L.K. J. Immunol. (1999) [Pubmed]
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