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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

In vivo brain myo-inositol levels in children with Down syndrome.

The Na+/myo-inositol cotransporter (SLC5A3) gene, located on the long arm of human chromosome 21, may play a key role in osmoregulation including the regulation of levels of the "idiogenic osmole," myo-inositol, in brain cells. To determine whether the levels of myo-inositol are increased in the basal ganglia of children with Down syndrome, we performed in vivo brain hydrogen 1-nuclear magnetic resonance or 1H-magnetic resonance spectroscopy and measured plasma osmolality in a cohort of children with trisomy 21. Myo-inositol is elevated in the corpus striatum of infants and children with Down syndrome, even in the absence of hypertonic stress.[1]


  1. In vivo brain myo-inositol levels in children with Down syndrome. Berry, G.T., Wang, Z.J., Dreha, S.F., Finucane, B.M., Zimmerman, R.A. J. Pediatr. (1999) [Pubmed]
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