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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus.

Cyclin-dependent kinases (CDKs) activate the firing of replication origins during the S phase of the cell cycle. They also block re-initiation of DNA replication within a single cell cycle, by preventing the assembly of prereplicative complexes at origins. We show here that, in budding yeast, CDKs exclude the essential prereplicative-complex component Mcm4 from the nucleus. Although origin firing can be triggered by the B-type cyclins only, both G1-phase and B-type cyclins cause exit of Mcm4 from the nucleus. These results suggest that G1 cyclins may diminish the cell's capacity to assemble prereplicative complexes before B-type cyclins trigger origin firing during S phase.[1]

References

  1. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Labib, K., Diffley, J.F., Kearsey, S.E. Nat. Cell Biol. (1999) [Pubmed]
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