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Gene Review

MCM4  -  MCM DNA helicase complex subunit MCM4

Saccharomyces cerevisiae S288c

Synonyms: CDC54, Cell division control protein 54, DNA replication licensing factor MCM4, HCD21, YP9531.13, ...
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High impact information on CDC54


Biological context of CDC54


Other interactions of CDC54

  • Comparison of Cdc54p to related proteins from other species revealed that it closely resembles cdc21p from Schizosaccharomyces pombe [3].
  • It is likely that pre-RCs contain heteromeric complexes of MCM2-7 proteins, since degradation of Mcm2, 3, 6, or 7 during G1-phase, after pre-RC formation, causes loss of Mcm4 from the nucleus [7].

Analytical, diagnostic and therapeutic context of CDC54

  • These toroidal structures are distinct from that of the Mcm4/6/7 hexamer, which was also examined by electron microscopy [8].


  1. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Labib, K., Diffley, J.F., Kearsey, S.E. Nat. Cell Biol. (1999) [Pubmed]
  2. Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18. Kearsey, S.E., Montgomery, S., Labib, K., Lindner, K. EMBO J. (2000) [Pubmed]
  3. Cdc54 belongs to the Cdc46/Mcm3 family of proteins which are essential for initiation of eukaryotic DNA replication. Whitebread, L.A., Dalton, S. Gene (1995) [Pubmed]
  4. The F-box protein Met30 is required for multiple steps in the budding yeast cell cycle. Su, N.Y., Flick, K., Kaiser, P. Mol. Cell. Biol. (2005) [Pubmed]
  5. Essential role of MCM proteins in premeiotic DNA replication. Lindner, K., Gregán, J., Montgomery, S., Kearsey, S.E. Mol. Biol. Cell (2002) [Pubmed]
  6. Identification of an MCM4 homologue expressed specifically in the sexual stage of Plasmodium falciparum. Li, J.L., Cox, L.S. Int. J. Parasitol. (2001) [Pubmed]
  7. MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint. Labib, K., Kearsey, S.E., Diffley, J.F. Mol. Biol. Cell (2001) [Pubmed]
  8. Mammalian Mcm2/4/6/7 complex forms a toroidal structure. Yabuta, N., Kajimura, N., Mayanagi, K., Sato, M., Gotow, T., Uchiyama, Y., Ishimi, Y., Nojima, H. Genes Cells (2003) [Pubmed]
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