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Nakanishi, Y. et al.

Nakanishi, Kawasaki, Bai, Takayama, Pei, Takano, Inoue, Osaki, Hara, Kiyohara,

Expression of p53 and glutathione S-transferase-pi relates to clinical drug resistance in non-small cell lung cancer.

To determine the predictive value of the expression of p53 and glutathione S-transferase-pi (GST-pi) with respect to chemotherapy response, immunostaining was performed on transbronchial biopsy specimens from previously untreated patients with non-small cell lung cancer. Of the 54 patients, 34 patients (63%) and 37 patients (69%) were positive for p53 and GST-pi, respectively. The response rates in the p53-positive and p53-negative group were 15 and 45%, and those in GST-pi-positive and GST-pi-negative groups were 16 and 47%, respectively. A multiple logistic regression analysis revealed that positive immunostaining for GST-pi was a significant risk factor for clinical chemotherapy resistance. The combination of these two markers was the most important independent factor in predicting a response to chemotherapy in multiple logistic regression analysis. Immunohistochemical expression of p53 and GST-pi was independently related to clinical chemoresistance in patients with non-small cell lung cancer. Combined use of these two biomarkers may be a useful predictor of clinical chemoresistance. Copyright Copyright 1999 S. Karger AG, Basel[1]

References

Expression of p53 and glutathione S-transferase-pi relates to clinical drug resistance in non-small cell lung cancer. Nakanishi, Y., Kawasaki, M., Bai, F., Takayama, K., Pei, X.H., Takano, K., Inoue, K., Osaki, S., Hara, N., Kiyohara, C. Oncology (1999) [Pubmed]

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