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MeSH Review

Logistic Models

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Disease relevance of Logistic Models


Psychiatry related information on Logistic Models


High impact information on Logistic Models


Chemical compound and disease context of Logistic Models

  • (a) A logistic regression analysis showed that a formulation of time was an independent statistically significant variable (P = 0.025) in addition to the total number of sites of metastasis (P less than 0.001) and pretreatment values of human chorionic gonadotropin (P less than 0.001) and lactate dehydrogenase (P = 0.002) [16].
  • There was a trend to higher tumor response rates in patients treated with MTX before 5-FU (45% v 33% overall; 65% v 39% in patients with previously untreated head and neck cancer), but these differences were not significant, either by chi-square test or by multivariate stepwise logistic regression [17].
  • No significant association was observed between either short-term (1-14 years) or long-term (15+ years) menthol use and lung cancer in logistic regression analyses adjusting for covariates [18].
  • A multivariate logistic regression analysis of the confirmed complete remissions on pentostatin showed the following factors to be important for achieving a complete remission: high hemoglobin level (two-tailed P = .024), young age (P = .0085), and no or little splenomegaly (P = .0029) [19].
  • A logistic regression model, validated by Monte Carlo simulation, identified 3 factors, proteinuria, elevated ESR, and low carbon monoxide diffusing capacity, that in combination, had an accuracy of >80% in predicting mortality [20].

Biological context of Logistic Models


Anatomical context of Logistic Models

  • Postmenopausal estrogen replacement was a significant independent protective factor for coronary artery disease in a multivariate logistic regression model (P = 0.037) [26].
  • Among nine clinical, 20 hemodynamic, and six procedural variables, stepwise logistic regression analysis selected the following as independent predictors of AS: smaller increases in valve area (p = 0.01) after PMV, absence of previous surgical commissurotomy (p = 0.02), mitral valve calcification (p = 0.02), and smaller left atria (p = 0.06) [27].
  • In a forward stepwise Cox logistic regression analysis, clinical stage IIIB or greater (hazard ratio of 4.5, P <.001), pathologic involvement of four or more lymph nodes (hazard ratio of 2.7, P =.008), and no use of tamoxifen (hazard ratio of 3.9, P =.027) independently predicted for LRR [28].
  • G-CSF accelerated recovery to > or = 1,000 neutrophils (P < .0001; median, 34 days for FA, 21 days for FLAG), but logistic regression provided no evidence that the CR rate was higher with FLAG than with FA (P = .50), with unadjusted CR rates of 63% and 53%, respectively [29].
  • The logistic regression analysis presented in this paper illustrates that those individuals who showed large increases in retinol, riboflavin, and zinc blood levels were more likely to have a histologically normal esophagus at the end of the trial [30].

Associations of Logistic Models with chemical compounds


Gene context of Logistic Models

  • Stepwise logistic-regression analysis showed that the association could be explained by either DRB1 or DQA1 but not by DQB1 [36].
  • Logistic regression analysis of SNP data across GRIN2A and ABAT showed a trend toward haplotypic differences between cases and controls [37].
  • Finally, these results were also consistent with the results from the conditional logistic regression, which confirmed the interaction between GABRA4 and GABRB1 (odds ratio = 2.9 for interaction term; P = .002) [38].
  • Multiple logistic regression demonstrated an increased risk of AMD in carriers of the G allele at TLR4 residue 299 (odds ratio=2.65, P=0.025), but lack of an independent effect by T399I variant [39].
  • Multivariate logistic regression analysis showed that engraftment was associated with marrow matched at HLA-A, HLA-B, and DRB1; higher cell dose; younger recipient; male recipient; and recipient from a non-African American ethnic group [40].

Analytical, diagnostic and therapeutic context of Logistic Models


  1. The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in patients with non-insulin-dependent diabetes and hypertension. Estacio, R.O., Jeffers, B.W., Hiatt, W.R., Biggerstaff, S.L., Gifford, N., Schrier, R.W. N. Engl. J. Med. (1998) [Pubmed]
  2. Blood levels of organochlorine residues and risk of breast cancer. Wolff, M.S., Toniolo, P.G., Lee, E.W., Rivera, M., Dubin, N. J. Natl. Cancer Inst. (1993) [Pubmed]
  3. Increased risk of 'high-risk' colorectal adenomas in overweight men. Bayerdörffer, E., Mannes, G.A., Ochsenkühn, T., Köpcke, W., Wiebecke, B., Paumgartner, G. Gastroenterology (1993) [Pubmed]
  4. Angiographic and hemodynamic determinants of myocardial ischemia during adenosine thallium-201 scintigraphy in coronary artery disease. Nishimura, S., Kimball, K.T., Mahmarian, J.J., Verani, M.S. Circulation (1993) [Pubmed]
  5. Effect of cholesterol reduction on myocardial ischemia in patients with coronary disease. Andrews, T.C., Raby, K., Barry, J., Naimi, C.L., Allred, E., Ganz, P., Selwyn, A.P. Circulation (1997) [Pubmed]
  6. Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. Sarkar, S., Mitlak, B.H., Wong, M., Stock, J.L., Black, D.M., Harper, K.D. J. Bone Miner. Res. (2002) [Pubmed]
  7. J-shaped relationship between mortality and admission blood pressure in black patients with acute stroke. M'Buyamba-Kabangu, J.R., Longo-Mbenza, B., Tambwe, M.J., Dikassa, L.N., Mbala-Mukendi, M. J. Hypertens. (1995) [Pubmed]
  8. Predictors of response to pharmacotherapy in social anxiety disorder: an analysis of 3 placebo-controlled paroxetine trials. Stein, D.J., Stein, M.B., Pitts, C.D., Kumar, R., Hunter, B. The Journal of clinical psychiatry. (2002) [Pubmed]
  9. Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine. Nelson, J.C., Portera, L., Leon, A.C. The Journal of clinical psychiatry. (2005) [Pubmed]
  10. Estrogen use and early onset Alzheimer's disease: a population-based study. Slooter, A.J., Bronzova, J., Witteman, J.C., Van Broeckhoven, C., Hofman, A., van Duijn, C.M. J. Neurol. Neurosurg. Psychiatr. (1999) [Pubmed]
  11. Use of copper intrauterine devices and the risk of tubal infertility among nulligravid women. Hubacher, D., Lara-Ricalde, R., Taylor, D.J., Guerra-Infante, F., Guzmán-Rodríguez, R. N. Engl. J. Med. (2001) [Pubmed]
  12. Clinical findings with implications for genetic testing in families with clustering of colorectal cancer. Wijnen, J.T., Vasen, H.F., Khan, P.M., Zwinderman, A.H., van der Klift, H., Mulder, A., Tops, C., Møller, P., Fodde, R. N. Engl. J. Med. (1998) [Pubmed]
  13. The intensity of hemodialysis and the response to erythropoietin in patients with end-stage renal disease. Ifudu, O., Feldman, J., Friedman, E.A. N. Engl. J. Med. (1996) [Pubmed]
  14. Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease. Okuizumi, K., Onodera, O., Namba, Y., Ikeda, K., Yamamoto, T., Seki, K., Ueki, A., Nanko, S., Tanaka, H., Takahashi, H., Oyanagi, K., Mizusawa, H., Kanazawa, I., Tsuji, S. Nat. Genet. (1995) [Pubmed]
  15. Elevation of serum creatine kinase in divers with arterial gas embolization. Smith, R.M., Neuman, T.S. N. Engl. J. Med. (1994) [Pubmed]
  16. Stage migration and the increasing proportion of complete responders in patients with advanced germ cell tumors. Bosl, G.J., Geller, N.L., Chan, E.Y. Cancer Res. (1988) [Pubmed]
  17. Combination therapy with methotrexate and 5-fluorouracil: a prospective randomized clinical trial of order of administration. Coates, A.S., Tattersall, M.H., Swanson, C., Hedley, D., Fox, R.M., Raghavan, D. J. Clin. Oncol. (1984) [Pubmed]
  18. Use of mentholated cigarettes and lung cancer risk. Kabat, G.C., Hebert, J.R. Cancer Res. (1991) [Pubmed]
  19. Randomized comparison of pentostatin versus interferon alfa-2a in previously untreated patients with hairy cell leukemia: an intergroup study. Grever, M., Kopecky, K., Foucar, M.K., Head, D., Bennett, J.M., Hutchison, R.E., Corbett, W.E., Cassileth, P.A., Habermann, T., Golomb, H. J. Clin. Oncol. (1995) [Pubmed]
  20. Prediction of five-year survival following presentation with scleroderma: development of a simple model using three disease factors at first visit. Bryan, C., Knight, C., Black, C.M., Silman, A.J. Arthritis Rheum. (1999) [Pubmed]
  21. Asbestos exposure-cigarette smoking interactions among shipyard workers. Blanc, P.D., Golden, J.A., Gamsu, G., Aberle, D.R., Gold, W.M. JAMA (1988) [Pubmed]
  22. Carotid arteriosclerosis in identical twins discordant for cigarette smoking. Haapanen, A., Koskenvuo, M., Kaprio, J., Kesäniemi, Y.A., Heikkilä, K. Circulation (1989) [Pubmed]
  23. Common DNase I polymorphism associated with autoantibody production among systemic lupus erythematosus patients. Shin, H.D., Park, B.L., Kim, L.H., Lee, H.S., Kim, T.Y., Bae, S.C. Hum. Mol. Genet. (2004) [Pubmed]
  24. Does platelet-derived growth factor-A chain stimulate proliferation of arterial mesenchymal cells in human atherosclerotic plaques? Rekhter, M.D., Gordon, D. Circ. Res. (1994) [Pubmed]
  25. Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. Ratnasinghe, D., Tangrea, J.A., Andersen, M.R., Barrett, M.J., Virtamo, J., Taylor, P.R., Albanes, D. Cancer Res. (2000) [Pubmed]
  26. Postmenopausal estrogen use and coronary atherosclerosis. Sullivan, J.M., Vander Zwaag, R., Lemp, G.F., Hughes, J.P., Maddock, V., Kroetz, F.W., Ramanathan, K.B., Mirvis, D.M. Ann. Intern. Med. (1988) [Pubmed]
  27. Left-to-right atrial shunting after percutaneous mitral valvuloplasty. Incidence and long-term hemodynamic follow-up. Cequier, A., Bonan, R., Serra, A., Dyrda, I., Crépeau, J., Dethy, M., Waters, D. Circulation (1990) [Pubmed]
  28. Predictors of local-regional recurrence after neoadjuvant chemotherapy and mastectomy without radiation. Buchholz, T.A., Tucker, S.L., Masullo, L., Kuerer, H.M., Erwin, J., Salas, J., Frye, D., Strom, E.A., McNeese, M.D., Perkins, G., Katz, A., Singletary, S.E., Hunt, K.K., Buzdar, A.U., Hortobagyi, G.N. J. Clin. Oncol. (2002) [Pubmed]
  29. Use of granulocyte colony-stimulating factor before, during, and after fludarabine plus cytarabine induction therapy of newly diagnosed acute myelogenous leukemia or myelodysplastic syndromes: comparison with fludarabine plus cytarabine without granulocyte colony-stimulating factor. Estey, E., Thall, P., Andreeff, M., Beran, M., Kantarjian, H., O'Brien, S., Escudier, S., Robertson, L.E., Koller, C., Kornblau, S. J. Clin. Oncol. (1994) [Pubmed]
  30. Blood, retinol and zinc riboflavin status in relation to precancerous lesions of the esophagus: findings from a vitamin intervention trial in the People's Republic of China. Wahrendorf, J., Muñoz, N., Lu, J.B., Thurnham, D.I., Crespi, M., Bosch, F.X. Cancer Res. (1988) [Pubmed]
  31. Homicide in New York City. Cocaine use and firearms. Tardiff, K., Marzuk, P.M., Leon, A.C., Hirsch, C.S., Stajic, M., Portera, L., Hartwell, N. JAMA (1994) [Pubmed]
  32. Low-density lipoprotein subclass patterns and risk of myocardial infarction. Austin, M.A., Breslow, J.L., Hennekens, C.H., Buring, J.E., Willett, W.C., Krauss, R.M. JAMA (1988) [Pubmed]
  33. Apolipoprotein(a) phenotypes, Lp(a) concentration and plasma lipid levels in relation to coronary heart disease in a Chinese population: evidence for the role of the apo(a) gene in coronary heart disease. Sandholzer, C., Boerwinkle, E., Saha, N., Tong, M.C., Utermann, G. J. Clin. Invest. (1992) [Pubmed]
  34. Urokinase-type plasminogen activator and its inhibitor PAI-1: predictors of poor response to tamoxifen therapy in recurrent breast cancer. Foekens, J.A., Look, M.P., Peters, H.A., van Putten, W.L., Portengen, H., Klijn, J.G. J. Natl. Cancer Inst. (1995) [Pubmed]
  35. p53 protein accumulation and gene mutation in the progression of human prostate carcinoma. Navone, N.M., Troncoso, P., Pisters, L.L., Goodrow, T.L., Palmer, J.L., Nichols, W.W., von Eschenbach, A.C., Conti, C.J. J. Natl. Cancer Inst. (1993) [Pubmed]
  36. Regression mapping of association between the human leukocyte antigen region and Graves disease. Simmonds, M.J., Howson, J.M., Heward, J.M., Cordell, H.J., Foxall, H., Carr-Smith, J., Gibson, S.M., Walker, N., Tomer, Y., Franklyn, J.A., Todd, J.A., Gough, S.C. Am. J. Hum. Genet. (2005) [Pubmed]
  37. Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT. Barnby, G., Abbott, A., Sykes, N., Morris, A., Weeks, D.E., Mott, R., Lamb, J., Bailey, A.J., Monaco, A.P. Am. J. Hum. Genet. (2005) [Pubmed]
  38. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Ma, D.Q., Whitehead, P.L., Menold, M.M., Martin, E.R., Ashley-Koch, A.E., Mei, H., Ritchie, M.D., Delong, G.R., Abramson, R.K., Wright, H.H., Cuccaro, M.L., Hussman, J.P., Gilbert, J.R., Pericak-Vance, M.A. Am. J. Hum. Genet. (2005) [Pubmed]
  39. Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Zareparsi, S., Buraczynska, M., Branham, K.E., Shah, S., Eng, D., Li, M., Pawar, H., Yashar, B.M., Moroi, S.E., Lichter, P.R., Petty, H.R., Richards, J.E., Abecasis, G.R., Elner, V.M., Swaroop, A. Hum. Mol. Genet. (2005) [Pubmed]
  40. Engraftment and survival after unrelated-donor bone marrow transplantation: a report from the national marrow donor program. Davies, S.M., Kollman, C., Anasetti, C., Antin, J.H., Gajewski, J., Casper, J.T., Nademanee, A., Noreen, H., King, R., Confer, D., Kernan, N.A. Blood (2000) [Pubmed]
  41. Risk of venous thromboembolism in users of hormone replacement therapy. Daly, E., Vessey, M.P., Hawkins, M.M., Carson, J.L., Gough, P., Marsh, S. Lancet (1996) [Pubmed]
  42. Hyperinsulinemic microalbuminuria. A new risk indicator for coronary heart disease. Kuusisto, J., Mykkänen, L., Pyörälä, K., Laakso, M. Circulation (1995) [Pubmed]
  43. Urinary VEGF and MMP levels as predictive markers of 1-year progression-free survival in cancer patients treated with radiation therapy: a longitudinal study of protein kinetics throughout tumor progression and therapy. Chan, L.W., Moses, M.A., Goley, E., Sproull, M., Muanza, T., Coleman, C.N., Figg, W.D., Albert, P.S., Ménard, C., Camphausen, K. J. Clin. Oncol. (2004) [Pubmed]
  44. A simple modification in operative technique can reduce the incidence of nonanastomotic biliary strictures after orthotopic liver transplantation. Sankary, H.N., McChesney, L., Frye, E., Cohn, S., Foster, P., Williams, J. Hepatology (1995) [Pubmed]
  45. Outcome and prognostic markers in severe drug-induced liver disease. Björnsson, E., Olsson, R. Hepatology (2005) [Pubmed]
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