Gene Review:
GSTP1 - glutathione S-transferase pi 1
Homo sapiens
Synonyms:
DFN7, FAEES3, GST class-pi, GST3, GSTP, ...
Townsend,
Kabler,
Doehmer,
Morrow,
Esteller,
Spivack,
Hurteau,
Jain,
Kumar,
Aldous,
Gierthy,
Kaminsky,
Bastian,
Ellinger,
Wellmann,
Wernert,
Heukamp,
Müller,
von Ruecker,
Ertunc,
Aban,
Tok,
Tamer,
Arslan,
Dilek,
Lodovici,
Luceri,
Guglielmi,
Bacci,
Akpan,
Fonnesu,
Boddi,
Dolara,
Zuntar,
Kalanj-Bognar,
Topić,
Petlevski,
Stefanović,
Demarin,
- Association between glutathione S-transferase M1, P1, and T1 genetic polymorphisms and development of breast cancer. Helzlsouer, K.J., Selmin, O., Huang, H.Y., Strickland, P.T., Hoffman, S., Alberg, A.J., Watson, M., Comstock, G.W., Bell, D. J. Natl. Cancer Inst. (1998)
- Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer. Stoehlmacher, J., Park, D.J., Zhang, W., Groshen, S., Tsao-Wei, D.D., Yu, M.C., Lenz, H.J. J. Natl. Cancer Inst. (2002)
- Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett's esophagus and esophageal carcinoma. van Lieshout, E.M., Roelofs, H.M., Dekker, S., Mulder, C.J., Wobbes, T., Jansen, J.B., Peters, W.H. Cancer Res. (1999)
- Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci. Bastian, P.J., Ellinger, J., Wellmann, A., Wernert, N., Heukamp, L.C., Müller, S.C., von Ruecker, A. Clin. Cancer Res. (2005)
- Association of GSTP1 polymorphism and survival for esophageal cancer. Lee, J.M., Wu, M.T., Lee, Y.C., Yang, S.Y., Chen, J.S., Hsu, H.H., Huang, P.M., Kuo, S.W., Lee, C.J., Chen, C.J. Clin. Cancer Res. (2005)
- Possible genetic damage in the Czech nuclear power plant workers. Sram, R.J., Rössner, P., Rubes, J., Beskid, O., Dusek, Z., Chvatalova, I., Schmuczerova, J., Milcova, A., Solansky, I., Bavorova, H., Ocadlikova, D., Kopecna, O., Musilova, P. Mutat. Res. (2006)
- The glutathione S-transferase polymorphisms in a control population and in Alzheimer's disease patients. Zuntar, I., Kalanj-Bognar, S., Topić, E., Petlevski, R., Stefanović, M., Demarin, V. Clin. Chem. Lab. Med. (2004)
- Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1. Cumming, R.C., Lightfoot, J., Beard, K., Youssoufian, H., O'Brien, P.J., Buchwald, M. Nat. Med. (2001)
- Aberrant DNA methylation as a cancer-inducing mechanism. Esteller, M. Annu. Rev. Pharmacol. Toxicol. (2005)
- Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. Nakayama, M., Bennett, C.J., Hicks, J.L., Epstein, J.I., Platz, E.A., Nelson, W.G., De Marzo, A.M. Am. J. Pathol. (2003)
- Glutathione S-transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers. Sikdar, N., Paul, R.R., Roy, B. Int. J. Cancer (2004)
- Glutathione-S-transferase P1 gene polymorphism and susceptibility to endometriosis. Ertunc, D., Aban, M., Tok, E.C., Tamer, L., Arslan, M., Dilek, S. Hum. Reprod. (2005)
- Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. Hengstler, J.G., Arand, M., Herrero, M.E., Oesch, F. Recent Results Cancer Res. (1998)
- Prognostic value of p53, glutathione S-transferase pi, and thymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer. Shiga, H., Heath, E.I., Rasmussen, A.A., Trock, B., Johnston, P.G., Forastiere, A.A., Langmacher, M., Baylor, A., Lee, M., Cullen, K.J. Clin. Cancer Res. (1999)
- Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas. Sarmanová, J., Benesová, K., Gut, I., Nedelcheva-Kristensen, V., Tynková, L., Soucek, P. Hum. Mol. Genet. (2001)
- Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells. Lin, X., Nelson, W.G. Cancer Res. (2003)
- Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells. Bakker, J., Lin, X., Nelson, W.G. J. Biol. Chem. (2002)
- High gene expression of TS1, GSTP1, and ERCC1 are risk factors for survival in patients treated with trimodality therapy for esophageal cancer. Joshi, M.B., Shirota, Y., Danenberg, K.D., Conlon, D.H., Salonga, D.S., Herndon, J.E., Danenberg, P.V., Harpole, D.H. Clin. Cancer Res. (2005)
- Role of glutathione S-transferase P1, P-glycoprotein and multidrug resistance-associated protein 1 in acquired doxorubicin resistance. Harbottle, A., Daly, A.K., Atherton, K., Campbell, F.C. Int. J. Cancer (2001)
- Glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes and the risk of smoking-related oral and pharyngeal cancers. Jourenkova-Mironova, N., Voho, A., Bouchardy, C., Wikman, H., Dayer, P., Benhamou, S., Hirvonen, A. Int. J. Cancer (1999)
- Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTM2 by butyrate. Ebert, M.N., Klinder, A., Peters, W.H., Schäferhenrich, A., Sendt, W., Scheele, J., Pool-Zobel, B.L. Carcinogenesis (2003)
- Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. Glasgow, S.C., Yu, J., Carvalho, L.P., Shannon, W.D., Fleshman, J.W., McLeod, H.L. Br. J. Cancer (2005)
- Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH. Lodovici, M., Luceri, C., Guglielmi, F., Bacci, C., Akpan, V., Fonnesu, M.L., Boddi, V., Dolara, P. Cancer Epidemiol. Biomarkers Prev. (2004)
- Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye. Bhosale, P., Larson, A.J., Frederick, J.M., Southwick, K., Thulin, C.D., Bernstein, P.S. J. Biol. Chem. (2004)
- Regulation of the Fanconi anemia group C protein through proteolytic modification. Brodeur, I., Goulet, I., Tremblay, C.S., Charbonneau, C., Delisle, M.C., Godin, C., Huard, C., Khandjian, E.W., Buchwald, M., Lévesque, G., Carreau, M. J. Biol. Chem. (2004)
- Cytosine methylation represses glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells. Singal, R., van Wert, J., Bashambu, M. Cancer Res. (2001)
- Transcriptional and post-transcriptional regulation of glutathione S-transferase P1 expression during butyric acid-induced differentiation of K562 cells. Schnekenburger, M., Morceau, F., Henry, E., Blasius, R., Dicato, M., Trentesaux, C., Diederich, M. Leuk. Res. (2006)
- Synergistic effects of zeaxanthin and its binding protein in the prevention of lipid membrane oxidation. Bhosale, P., Bernstein, P.S. Biochim. Biophys. Acta (2005)
- Expression of cytochromes P450 and glutathione S-transferases in human prostate, and the potential for activation of heterocyclic amine carcinogens via acetyl-coA-, PAPS- and ATP-dependent pathways. Di Paolo, O.A., Teitel, C.H., Nowell, S., Coles, B.F., Kadlubar, F.F. Int. J. Cancer (2005)
- Characterization of the molecular forms of glutathione S-transferase P1 in human gastric cancer cells (Kato III) and in normal human erythrocytes. Ranganathan, P.N., Whalen, R., Boyer, T.D. Biochem. J. (2005)
- Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells. Jhaveri, M.S., Morrow, C.S. Gene (1998)
- Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines. Townsend, A.J., Kabler, S.L., Doehmer, J., Morrow, C.S. Toxicology (2002)
- Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases. Sundberg, K., Dreij, K., Seidel, A., Jernström, B. Chem. Res. Toxicol. (2002)
- Immunohistochemical localization of glutathione S-transferases in human lung. Anttila, S., Hirvonen, A., Vainio, H., Husgafvel-Pursiainen, K., Hayes, J.D., Ketterer, B. Cancer Res. (1993)
- Candidate genetic modifiers of individual susceptibility to renal cell carcinoma: a study of polymorphic human xenobiotic-metabolizing enzymes. Longuemaux, S., Deloménie, C., Gallou, C., Méjean, A., Vincent-Viry, M., Bouvier, R., Droz, D., Krishnamoorthy, R., Galteau, M.M., Junien, C., Béroud, C., Dupret, J.M. Cancer Res. (1999)
- Gene-environment interaction signatures by quantitative mRNA profiling in exfoliated buccal mucosal cells. Spivack, S.D., Hurteau, G.J., Jain, R., Kumar, S.V., Aldous, K.M., Gierthy, J.F., Kaminsky, L.S. Cancer Res. (2004)
- Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. Lee, S., Kim, W.H., Jung, H.Y., Yang, M.H., Kang, G.H. Am. J. Pathol. (2002)
- A quantitative promoter methylation profile of prostate cancer. Jerónimo, C., Henrique, R., Hoque, M.O., Mambo, E., Ribeiro, F.R., Varzim, G., Oliveira, J., Teixeira, M.R., Lopes, C., Sidransky, D. Clin. Cancer Res. (2004)
- Glutathione S-transferase P1 genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukaemia. Krajinovic, M., Labuda, D., Sinnett, D. Pharmacogenetics (2002)