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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo.

Subsets of murine CD4+ T cells localize to different areas of the spleen after adoptive transfer. Naïve and T helper 1 (TH1) cells, which express the chemokine receptor CCR7, are home to the periarteriolar lymphoid sheath, whereas activated TH2 cells, which lack CCR7, form rings at the periphery of the T cell zones near B cell follicles. Retroviral transduction of TH2 cells with CCR7 forces them to localize in a TH1-like pattern and inhibits their participation in B cell help in vivo but not in vitro. Thus, differential expression of chemokine receptors results in unique cellular migration patterns that are important for effective immune responses.[1]

References

  1. The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo. Randolph, D.A., Huang, G., Carruthers, C.J., Bromley, L.E., Chaplin, D.D. Science (1999) [Pubmed]
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