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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Purkinje cell degeneration, a new neurological mutation in the mouse.

A new autosomal recessive mouse mutation, Purkinje cell degeneration (pcd), is described. Mutants exhibit a moderate ataxia beginning at 3 to 4 weeks of age. The ataxia results from postnatal degeneration of virtually all cerebellar Purkinje cells beginning around 15 to 18 days of age and progressing rapidly over the next 2 weeks. In addition to the cerebellar disease there is slow progressive degeneration in the retina (photoreceptor cells) and olfactory bulb. Also, adult males have abnormal sperm.[1]


  1. Purkinje cell degeneration, a new neurological mutation in the mouse. Mullen, R.J., Eicher, E.M., Sidman, R.L. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
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