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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

GPR1 regulates filamentous growth through FLO11 in yeast Saccharomyces cerevisiae.

Cell growth and differentiation are regulated by nutrient availability in the yeast Saccharomyces cerevisiae. Under conditions of nitrogen limitation, diploid cells of S. cerevisiae differentiate to a filamentous growth known as a pseudohyphal growth, while haploid cells produce invasive filaments which penetrate the agar in nutrient-rich medium. We have found that GPR1, which encodes a putative G-protein-coupled receptor, is required for both pseudohyphal and invasive growth. Pseudohyphal growth was defective in Deltagpr1/Deltagpr1 mutant strain and this defect was reversed by addition of cAMP. Also, haploid Deltagpr1 mutant strain was defective in invasive growth. Northern blot analysis revealed that the transcriptional level of FLO11, which encodes a recently identified cell surface flocculin required for pseudohyphal growth, was reduced in Deltagpr1 mutant strain. These results indicate that GPR1 regulates both pseudohyphal and invasive growth by a cAMP-dependent mechanism.[1]


  1. GPR1 regulates filamentous growth through FLO11 in yeast Saccharomyces cerevisiae. Tamaki, H., Miwa, T., Shinozaki, M., Saito, M., Yun, C.W., Yamamoto, K., Kumagai, H. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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