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Gene Review

FLO1  -  Flo1p

Saccharomyces cerevisiae S288c

Synonyms: FLO2, FLO4, FLO8, Flocculation protein FLO1, Flocculin-1, ...
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Disease relevance of FLO1


High impact information on FLO1

  • These terminally repetitive regions consist of a telomeric repeat called W', flanked by DNA closely related to the yeast FLO1 gene [3].
  • Both pathways contribute to modulate the expression of the MUC1/FLO11 gene which encodes a cell-surface flocculin required for pseudohyphal and invasive growth [4].
  • PKA signals pseudohyphal growth, in part, by regulating Flo8-dependent expression of the cell surface flocculin Flo11 [5].
  • FLO11 encodes a cell surface flocculin with a structure similar to the class of yeast serine/threonine-rich GPI-anchored cell wall proteins [6].
  • We report here that the Gpr1 receptor is required for filamentous and haploid invasive growth and regulates expression of the cell surface flocculin Flo11 [7].

Biological context of FLO1


Anatomical context of FLO1


Associations of FLO1 with chemical compounds


Regulatory relationships of FLO1


Other interactions of FLO1

  • The sequencing of a 6619 bp region encoding for a flocculation gene previously cloned from a strain defined as FLO5 (Bidard et al., 1994) has revealed that it was a FLO1 gene [20].
  • It is thought that the FLO8 gene encodes a transcriptional activator of the dominant flocculation gene FLO1 in Saccharomyces cerevisiae [21].
  • The FLO11-encoded flocculin is required for a variety of important phenotypes in Saccharomyces cerevisiae, including flocculation, adhesion to agar and plastic, invasive growth, pseudohyphae formation and biofilm development [22].
  • Disruption of the FLO1 gene in the tup1 and ssn6 strains showed that one of the transcripts corresponded to the FLO1 gene [23].
  • The 3' end of the FLO1 gene was localized at approximately 24 kb from the right end of chromosome I, 20 kb centromere-proximal to PHO11 [1].

Analytical, diagnostic and therapeutic context of FLO1


  1. Physical localization of the flocculation gene FLO1 on chromosome I of Saccharomyces cerevisiae. Teunissen, A.W., van den Berg, J.A., Steensma, H.Y. Yeast (1993) [Pubmed]
  2. Cell Surface Expression of Bacterial Esterase A by Saccharomyces cerevisiae and Its Enhancement by Constitutive Activation of the Cellular Unfolded Protein Response. Breinig, F., Diehl, B., Rau, S., Zimmer, C., Schwab, H., Schmitt, M.J. Appl. Environ. Microbiol. (2006) [Pubmed]
  3. The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. Bussey, H., Kaback, D.B., Zhong, W., Vo, D.T., Clark, M.W., Fortin, N., Hall, J., Ouellette, B.F., Keng, T., Barton, A.B. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Control of pseudohyphae formation in Saccharomyces cerevisiae. Gancedo, J.M. FEMS Microbiol. Rev. (2001) [Pubmed]
  5. Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Pan, X., Heitman, J. Mol. Cell. Biol. (1999) [Pubmed]
  6. The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by Saccharomyces cerevisiae. Lo, W.S., Dranginis, A.M. Mol. Biol. Cell (1998) [Pubmed]
  7. The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Lorenz, M.C., Pan, X., Harashima, T., Cardenas, M.E., Xue, Y., Hirsch, J.P., Heitman, J. Genetics (2000) [Pubmed]
  8. Localization of the dominant flocculation genes FLO5 and FLO8 of Saccharomyces cerevisiae. Teunissen, A.W., van den Berg, J.A., Steensma, H.Y. Yeast (1995) [Pubmed]
  9. Genetic evidence of a new flocculation suppressor gene in Saccharomyces cerevisiae. Sieiro, C., Longo, E., Cansado, J., Velázquez, J.B., Calo, P., Blanco, P., Villa, T.G. FEMS Microbiol. Lett. (1993) [Pubmed]
  10. Molecular cloning and analysis of the yeast flocculation gene FLO1. Watari, J., Takata, Y., Ogawa, M., Sahara, H., Koshino, S., Onnela, M.L., Airaksinen, U., Jaatinen, R., Penttilä, M., Keränen, S. Yeast (1994) [Pubmed]
  11. Sequence of the open reading frame of the FLO1 gene from Saccharomyces cerevisiae. Teunissen, A.W., Holub, E., van der Hucht, J., van den Berg, J.A., Steensma, H.Y. Yeast (1993) [Pubmed]
  12. Possible mechanism for flocculation interactions governed by gene FLO1 in Saccharomyces cerevisiae. Miki, B.L., Poon, N.H., James, A.P., Seligy, V.L. J. Bacteriol. (1982) [Pubmed]
  13. Cloning and characterization of CAD1/AAF1, a gene from Candida albicans that induces adherence to endothelial cells after expression in Saccharomyces cerevisiae. Fu, Y., Filler, S.G., Spellberg, B.J., Fonzi, W., Ibrahim, A.S., Kanbe, T., Ghannoum, M.A., Edwards, J.E. Infect. Immun. (1998) [Pubmed]
  14. Localization and cell surface anchoring of the Saccharomyces cerevisiae flocculation protein Flo1p. Bony, M., Thines-Sempoux, D., Barre, P., Blondin, B. J. Bacteriol. (1997) [Pubmed]
  15. Evidence for two mechanisms of flocculation in Saccharomyces cerevisiae. Stratford, M. Yeast (1989) [Pubmed]
  16. Discrimination by heat and proteinase treatments between flocculent phenotypes conferred on Saccharomyces cerevisiae by the genes FLO1 and FLO5. Hodgson, J.A., Berry, D.R., Johnston, J.R. J. Gen. Microbiol. (1985) [Pubmed]
  17. FLO11 is essential for flor formation caused by the C-terminal deletion of NRG1 in Saccharomyces cerevisiae. Ishigami, M., Nakagawa, Y., Hayakawa, M., Iimura, Y. FEMS Microbiol. Lett. (2004) [Pubmed]
  18. The mechanism by which overexpression of Gts1p induces flocculation in a FLO8-inactive strain of the yeast Saccharomyces cerevisiae. Shen, H., Iha, H., Yaguchi, S., Tsurugi, K. FEMS Yeast Res. (2006) [Pubmed]
  19. Saccharomyces cerevisiae JEN1 promoter activity is inversely related to concentration of repressing sugar. Chambers, P., Issaka, A., Palecek, S.P. Appl. Environ. Microbiol. (2004) [Pubmed]
  20. The Saccharomyces cerevisiae FLO1 flocculation gene encodes for a cell surface protein. Bidard, F., Bony, M., Blondin, B., Dequin, S., Barre, P. Yeast (1995) [Pubmed]
  21. Analysis of the genes activated by the FLO8 gene in Saccharomyces cerevisiae. Kobayashi, O., Yoshimoto, H., Sone, H. Curr. Genet. (1999) [Pubmed]
  22. Characteristics of Flo11-dependent flocculation in Saccharomyces cerevisiae. Bayly, J.C., Douglas, L.M., Pretorius, I.S., Bauer, F.F., Dranginis, A.M. FEMS Yeast Res. (2005) [Pubmed]
  23. Transcriptional regulation of flocculation genes in Saccharomyces cerevisiae. Teunissen, A.W., van den Berg, J.A., Steensma, H.Y. Yeast (1995) [Pubmed]
  24. Distribution of the flocculation protein, flop, at the cell surface during yeast growth: the availability of flop determines the flocculation level. Bony, M., Barre, P., Blondin, B. Yeast (1998) [Pubmed]
  25. Cloning and analysis of a FLO5 flocculation gene from S. cerevisiae. Bidard, F., Blondin, B., Dequin, S., Vezinhet, F., Barre, P. Curr. Genet. (1994) [Pubmed]
  26. Isolation and characterization of a mutant of Saccharomyces cerevisiae affected in the FLO1 locus. Reboredo, N.M., Sieiro, C., Blanco, P., Villa, T.G. FEMS Microbiol. Lett. (1996) [Pubmed]
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