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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A role of glucocorticoid receptors in the guinea pig vestibular system.

To investigate glucocorticoid receptor ( GR) function in the vestibular periphery, GR antagonist RU38486 was administered to the guinea pig inner ear by osmotic pump, and we observed post-rotatory nystagmus (PRN) changes as a marker of vestibular function. Ten days after treatment, RU38486 (1 mM) resulted in ipsilateral vestibule hyperexcitability in response to rotation stimulation. This effect was dose-dependent. These data indicate that steroid hormones may play an important role in maintaining vestibular function.[1]

References

  1. A role of glucocorticoid receptors in the guinea pig vestibular system. Shimogori, H., Yamashita, H., Watanabe, T., Nakamura, S. Brain Res. (1999) [Pubmed]
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