Disease relevance of Nystagmus, Physiologic

• Point mutations in other parts of the gene CACNA1A were excluded and new clinical features of SCA6 reported--namely, central positional nystagmus and episodic ataxia responsive to acetazolamide [1].
• Myasthenia gravis: the effect of Tensilon on the caloric nystagmus response. Photoelectronystagmographic study [2].
• Using infrared CCD camera and electronystagmography we analyzed positional nystagmus in 33 patients with peripheral positional vertigo [3].
• In order to clarify changes in spontaneous and positional nystagmus which occurred during the course of peripheral labyrinthine diseases, 31 patients with Ménières disease (17 cases), aural vertigo of unknown etiology (9 cases), and sudden deafness (5 cases) were tested repeatedly using ENG [4].

High impact information on Nystagmus, Physiologic

• Per- and post-rotatory nystagmus induced by velocity step stimulation revealed an imperfect velocity-storage function in UL animals, which was modulated by baclofen [5].
• Of these patients, 187 (24%) were found to have positional nystagmus consistent with a diagnosis of BPPV [6].
• Other labyrinthine manifestations such as positional alcohol nystagmus, positional nystagmus with macroglobulinaemia and "heavy water" or glycerol ingestion occur because of a specific gravity differential between the cupula and the endolymph (buoyancy mechanism) [7].
• Ethanol inhibits vestibular and caloric nystagmus without affecting optokinetic nystagmus in rabbits [8].
• Metronidazole dosage ranged from 67.3 to 129.0 mg/kg of body weight/d. Clinical signs of toxicosis began with anorexia and intermittent vomiting and progressed rapidly to include pronounced, generalized ataxia and vertical, positional nystagmus [9].

Biological context of Nystagmus, Physiologic

• Accordingly, in human experiments styrene and toluene exposure did not elicit any positional nystagmus but caused an increased saccade speed and a diminished visual suppression of vestibular nystagmus [10].
• It is concluded that urea does not, like glycerol, cause an ageotropic direction changing positional nystagmus and allows for a more accurate evaluation of vestibular function following osmolar diuresis than glycerol does [11].
• All patients underwent conventional audiometric investigation, brainstem audiometry (ABR), electronystagmography including spontaneous, -gaze-, and positional nystagmus in darkness and under fixation, caloric tests with and without ocular fixation, pendular smooth pursuit test and saccade analyses [12].

Associations of Nystagmus, Physiologic with chemical compounds

• Effects of ethanol on optokinetic, vestibular and caloric nystagmus were investigated in pigmented rabbits to determine whether or not it affects a specific site involved in the induction of various nystagmus [8].
• During exposure to styrene a so-called positional nystagmus was demonstrated that indicated vestibular disturbances [13].
• Astemizole, a new H1 antihistamine, was tested on 10 patients with chronic dizziness and either spontaneous or positional nystagmus [14].
• Cocaine abusers had normal smooth pursuit, optokinetic nystagmus, vestibulo-ocular reflex, visual suppression of the vestibulo-ocular reflex, and caloric nystagmus [15].
• Of 14 patients with latent or positional nystagmus prior to the urea test, two lost their nystagmus, four showed marked decrease in slow component velocity, and eight were unchanged [11].

Gene context of Nystagmus, Physiologic

• Six of the 10 patients showed a clear decrease in spontaneous and/or positional nystagmus at the second and third ENG and a rebound of nystagmus when the drug was stopped [14].
• Observation of positional nystagmus with infrared CCD camera [3].
• The classification of SCD based on the neurotological findings including the findings of gaze test, positioning test, eye tracking test, OKN, and fixation suppression test of caloric nystagmus, was well correlated to the classification based on CT findings [16].
• The slow phase eye velocity (SPEV) and duration of post-rotatory nystagmus (PRN) were studied in squirrel monkeys (Saimiri sciureus) after a ramp speed rotation (0-200 degrees/sec, with 1 degree/sec2 angular acceleration) [17].

Analytical, diagnostic and therapeutic context of Nystagmus, Physiologic

• Latent and positional nystagmus were evaluated by electronystagmography before and after urea ingestion [11].

References