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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Bovine type I collagen as an endovascular stent-graft material: biocompatibility study in rabbits.

PURPOSE: To study the biocompatibility of a bovine type I collagen preparation as a material for small-vessel stent-grafts in rabbits. MATERIALS AND METHODS: A composite nitinol-collagen endovascular stent-graft with a 4-mm inner diameter was deployed in the abdominal aorta in nine rabbits. Angiography was performed, and the rabbits were sacrificed at 1, 2, and 7 days and at 1 and 3 months. The portion of the aorta containing the stent-graft was excised and was histologically evaluated. RESULTS: All stent-grafts were patent at all time points. On days 1, 2, and 7 after implantation, scattered red and white blood cells adhered to the stent-graft. At 1 month, the stent-graft was endothelialized and was infiltrated with fibroblasts that deposited collagen within the interstices of the implanted collagen material. At 3 months, there was additional collagen deposition within the interstices of the stent-graft that did not narrow the lumen of the stent-grafts. CONCLUSION: Type I collagen as a intravascular stent-graft material is biocompatible for at least 3 months in rabbits. It is rapidly endothelialized and does not cause reactive stenosis. As a versatile and biocompatible polymer, collagen is potentially useful in the construction of endovascular stent-grafts for use in human arteries.[1]


  1. Bovine type I collagen as an endovascular stent-graft material: biocompatibility study in rabbits. Cloft, H.J., Kallmes, D.F., Lin, H.B., Li, S.T., Marx, W.F., Hudson, S.B., Helm, G.A., Lopes, M.B., McGraw, J.K., Dion, J.E., Jensen, M.E. Radiology. (2000) [Pubmed]
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