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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The glucocorticoid receptor: rapid exchange with regulatory sites in living cells.

Steroid receptors bind to site-specific response elements in chromatin and modulate gene expression in a hormone-dependent fashion. With the use of a tandem array of mouse mammary tumor virus reporter elements and a form of glucocorticoid receptor labeled with green fluorescent protein, targeting of the receptor to response elements in live mouse cells was observed. Photobleaching experiments provide direct evidence that the hormone-occupied receptor undergoes rapid exchange between chromatin and the nucleoplasmic compartment. Thus, the interaction of regulatory proteins with target sites in chromatin is a more dynamic process than previously believed.[1]

References

  1. The glucocorticoid receptor: rapid exchange with regulatory sites in living cells. McNally, J.G., Müller, W.G., Walker, D., Wolford, R., Hager, G.L. Science (2000) [Pubmed]
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