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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Protein phosphatase 1beta is required for the maintenance of muscle attachments.

Type 1 serine/threonine protein phosphatases ( PP1) are important regulators of many cellular and developmental processes, including glycogen metabolism, muscle contraction, and the cell cycle [1] [2] [3] [4] [5]. Drosophila and humans both have multiple genes encoding PP1 isoforms [3] [6] [7]; each has one beta and several alpha isoform genes (alpha(1), alpha(2), alpha(3) in flies, alpha and gamma in humans; mammalian PP1beta is also known as PP1delta). The alpha/beta subtype differences are highly conserved between flies and mammals [6]. Though all these proteins are >85% identical to each other and have indistinguishable activities in vitro, we show here that the Drosophila beta isoform has a distinct biological role. We show that PP1beta9C corresponds to flapwing (flw), previously identified mutants of which are viable but flightless because of defects in indirect flight muscles (IFMs) [8]. We have isolated a new, semi-lethal flw allele that shows a range of defects, especially in muscles, which break away from their attachment sites and degenerate.[1]


  1. Protein phosphatase 1beta is required for the maintenance of muscle attachments. Raghavan, S., Williams, I., Aslam, H., Thomas, D., Szöor, B., Morgan, G., Gross, S., Turner, J., Fernandes, J., VijayRaghavan, K., Alphey, L. Curr. Biol. (2000) [Pubmed]
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