- Circulating levels of soluble CD30 are increased in patients with localized scleroderma and correlated with serological and clinical features of the disease. Ihn, H., Yazawa, N., Kubo, M., Yamane, K., Sato, S., Fujimoto, M., Kikuchi, K., Soma, Y., Tamaki, K. J. Rheumatol. (2000)