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MeSH Review

Scleroderma, Systemic

 
 
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Disease relevance of Scleroderma, Systemic

 

Psychiatry related information on Scleroderma, Systemic

 

High impact information on Scleroderma, Systemic

  • Furthermore, Y-chromosome sequences were identified in skin-biopsy specimens from 11 of 19 women with systemic sclerosis (58 percent); 9 of the 11 were known to have carried male fetuses [6].
  • Autoantibodies specific against fibrillarin, a 34-kD nucleolar protein associated with U3-snRNP, are present in patients with systemic sclerosis (SSc) [7].
  • Working with cultured dermal fibroblasts derived from control individuals and patients with systemic sclerosis (SSc), we have examined the effects of protein kinase C-delta (PKC-delta) on type I collagen biosynthesis and steady-state levels of COL1A1 and COL3A1 mRNAs [8].
  • AECA-positive/anti-PL antibody-negative sera from eight patients with systemic sclerosis (SS) and 21 control patients were evaluated [9].
  • Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III [10].
 

Chemical compound and disease context of Scleroderma, Systemic

 

Biological context of Scleroderma, Systemic

 

Anatomical context of Scleroderma, Systemic

 

Gene context of Scleroderma, Systemic

  • Association of polar amino acids at position 26 of the HLA-DQB1 first domain with the anticentromere autoantibody response in systemic sclerosis (scleroderma) [24].
  • Relative to normal pulmonary fibroblasts, fibroblasts cultured from scars of patients with the fibrotic disease systemic sclerosis (scleroderma) show enhanced ET-1 expression and binding [25].
  • Examination of the possible role of biologically relevant genes around FBN1 in systemic sclerosis in the Choctaw population [26].
  • Identification of an IL1A gene segment that determines aberrant constitutive expression of interleukin-1 alpha in systemic sclerosis [27].
  • OBJECTIVE: To describe the histopathologic and biochemical characteristics of skin from the Tsk2/+ mouse, a mutation with phenotypic features resembling those of systemic sclerosis (SSc), and to report the initial genetic mapping of the Tsk2 locus [28].
 

Analytical, diagnostic and therapeutic context of Scleroderma, Systemic

References

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  2. Nailfold capillary microscopy in mixed connective tissue disease. Comparison with systemic sclerosis and systemic lupus erythematosus. Granier, F., Vayssairat, M., Priollet, P., Housset, E. Arthritis Rheum. (1986) [Pubmed]
  3. Detection of autoantibodies to nucleolar transcription factor NOR 90/hUBF in sera of patients with rheumatic diseases, by recombinant autoantigen-based assays. Fujii, T., Mimori, T., Akizuki, M. Arthritis Rheum. (1996) [Pubmed]
  4. Monocyte chemoattractant protein 3 as a mediator of fibrosis: Overexpression in systemic sclerosis and the type 1 tight-skin mouse. Ong, V.H., Evans, L.A., Shiwen, X., Fisher, I.B., Rajkumar, V., Abraham, D.J., Black, C.M., Denton, C.P. Arthritis Rheum. (2003) [Pubmed]
  5. Erectile dysfunction associated with scleroderma: a case-control study of men with scleroderma and rheumatoid arthritis. Hong, P., Pope, J.E., Ouimet, J.M., Rullan, E., Seibold, J.R. J. Rheumatol. (2004) [Pubmed]
  6. Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis. Artlett, C.M., Smith, J.B., Jimenez, S.A. N. Engl. J. Med. (1998) [Pubmed]
  7. Antifibrillarin autoantibodies present in systemic sclerosis and other connective tissue diseases interact with similar epitopes. Kasturi, K.N., Hatakeyama, A., Spiera, H., Bona, C.A. J. Exp. Med. (1995) [Pubmed]
  8. Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. Jimenez, S.A., Gaidarova, S., Saitta, B., Sandorfi, N., Herrich, D.J., Rosenbloom, J.C., Kucich, U., Abrams, W.R., Rosenbloom, J. J. Clin. Invest. (2001) [Pubmed]
  9. The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis. Bordron, A., Dueymes, M., Levy, Y., Jamin, C., Leroy, J.P., Piette, J.C., Shoenfeld, Y., Youinou, P.Y. J. Clin. Invest. (1998) [Pubmed]
  10. Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III. Hirakata, M., Okano, Y., Pati, U., Suwa, A., Medsger, T.A., Hardin, J.A., Craft, J. J. Clin. Invest. (1993) [Pubmed]
  11. Prostacyclin increases cyclic-nucleotide responsiveness of lymphocytes from patients with systemic sclerosis. Kirby, J.D., Lima, D.R., Dowd, P.M., Kilfeather, S., Turner, P. Lancet (1980) [Pubmed]
  12. Absence of prostaglandin stimulated increase in acute phase proteins in systemic sclerosis. Whicher, J.T., Martin, M.F., Dieppe, P.A. Lancet (1980) [Pubmed]
  13. Diffusing capacity of the lung and nifedipine in systemic sclerosis. Sfikakis, P.P., Kyriakidis, M., Vergos, C., Papazoglou, S., Georgiakodis, F., Toutouzas, P., Sfikakis, P. Arthritis Rheum. (1990) [Pubmed]
  14. Microchimerism in Japanese women patients with systemic sclerosis. Murata, H., Nakauchi, H., Sumida, T. Lancet (1999) [Pubmed]
  15. Determination of an epitope of the diffuse systemic sclerosis marker antigen DNA topoisomerase I: sequence similarity with retroviral p30gag protein suggests a possible cause for autoimmunity in systemic sclerosis. Maul, G.G., Jimenez, S.A., Riggs, E., Ziemnicka-Kotula, D. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  16. Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. Leask, A., Abraham, D.J., Finlay, D.R., Holmes, A., Pennington, D., Shi-Wen, X., Chen, Y., Venstrom, K., Dou, X., Ponticos, M., Black, C., Bernabeu, C., Jackman, J.K., Findell, P.R., Connolly, M.K. Arthritis Rheum. (2002) [Pubmed]
  17. Autoantigenic epitopes on DNA topoisomerase I. Clinical and immunogenetic associations in systemic sclerosis. Kuwana, M., Kaburaki, J., Mimori, T., Tojo, T., Homma, M. Arthritis Rheum. (1993) [Pubmed]
  18. Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts. Mori, Y., Ishida, W., Bhattacharyya, S., Li, Y., Platanias, L.C., Varga, J. Arthritis Rheum. (2004) [Pubmed]
  19. Transcriptional activation of the alpha1(I) procollagen gene and up-regulation of alpha1(I) and alpha1(III) procollagen messenger RNA in dermal fibroblasts from tight skin 2 mice. Christner, P.J., Hitraya, E.G., Peters, J., McGrath, R., Jiménez, S.A. Arthritis Rheum. (1998) [Pubmed]
  20. Elevated serum BAFF levels in patients with systemic sclerosis: enhanced BAFF signaling in systemic sclerosis B lymphocytes. Matsushita, T., Hasegawa, M., Yanaba, K., Kodera, M., Takehara, K., Sato, S. Arthritis Rheum. (2006) [Pubmed]
  21. Autoantibodies to mitochondria in systemic sclerosis. Frequency and characterization using recombinant cloned autoantigen. Fregeau, D.R., Leung, P.S., Coppel, R.L., McNeilage, L.J., Medsger, T.A., Gershwin, M.E. Arthritis Rheum. (1988) [Pubmed]
  22. Elevated levels of eosinophil major basic protein in the sera of patients with systemic sclerosis. Cox, D., Earle, L., Jimenez, S.A., Leiferman, K.M., Gleich, G.J., Varga, J. Arthritis Rheum. (1995) [Pubmed]
  23. Lymphokine-activated killer cell and natural killer cell activities in patients with systemic sclerosis. Kantor, T.V., Whiteside, T.L., Friberg, D., Buckingham, R.B., Medsger, T.A. Arthritis Rheum. (1992) [Pubmed]
  24. Association of polar amino acids at position 26 of the HLA-DQB1 first domain with the anticentromere autoantibody response in systemic sclerosis (scleroderma). Reveille, J.D., Owerbach, D., Goldstein, R., Moreda, R., Isern, R.A., Arnett, F.C. J. Clin. Invest. (1992) [Pubmed]
  25. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Shi-Wen, X., Chen, Y., Denton, C.P., Eastwood, M., Renzoni, E.A., Bou-Gharios, G., Pearson, J.D., Dashwood, M., du Bois, R.M., Black, C.M., Leask, A., Abraham, D.J. Mol. Biol. Cell (2004) [Pubmed]
  26. Examination of the possible role of biologically relevant genes around FBN1 in systemic sclerosis in the Choctaw population. Tan, F.K., Tercero, G.M., Arnett, F.C., Wang, N., Chakraborty, R. Arthritis Rheum. (2003) [Pubmed]
  27. Identification of an IL1A gene segment that determines aberrant constitutive expression of interleukin-1 alpha in systemic sclerosis. Kawaguchi, Y., Hara, M., Kamatani, N., Wright, T.M. Arthritis Rheum. (2003) [Pubmed]
  28. The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration. Christner, P.J., Peters, J., Hawkins, D., Siracusa, L.D., Jiménez, S.A. Arthritis Rheum. (1995) [Pubmed]
  29. Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis. Kulozik, M., Hogg, A., Lankat-Buttgereit, B., Krieg, T. J. Clin. Invest. (1990) [Pubmed]
  30. Enzyme-linked immunosorbent assay for detection of anti-RNA polymerase III antibody: analytical accuracy and clinical associations in systemic sclerosis. Kuwana, M., Okano, Y., Pandey, J.P., Silver, R.M., Fertig, N., Medsger, T.A. Arthritis Rheum. (2005) [Pubmed]
  31. The effect of nifedipine on myocardial perfusion and metabolism in systemic sclerosis. A positron emission tomographic study. Duboc, D., Kahan, A., Maziere, B., Loc'h, C., Crouzel, C., Menkès, C.J., Amor, B., Strauch, G., Guérin, F., Syrota, A. Arthritis Rheum. (1991) [Pubmed]
  32. Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma). Reimer, G., Steen, V.D., Penning, C.A., Medsger, T.A., Tan, E.M. Arthritis Rheum. (1988) [Pubmed]
 
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