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MeSH Review

Scleroderma, Localized

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Disease relevance of Scleroderma, Localized


High impact information on Scleroderma, Localized

  • Immunoblotting confirmed the presence of IgG anti-topo IIalpha antibody in sera from patients with localized scleroderma and showed no cross-reactivity of anti-topo IIalpha antibody with topo I [6].
  • Eight patients with linear scleroderma (30%) and 6 patients with morphea (26%) had IgG autoantibodies to fibrillin 1 (rFbn-1) by RIA, compared with 3 controls (6%) (P = 0.006 and P = 0.022, respectively) [7].
  • Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin 1, in patients with localized scleroderma [7].
  • Among the disease groups studied, elevated levels of circulating TGF beta 1 were seen only in patients with morphea [8].
  • Serum levels of soluble interleukin-2 receptor. A marker of disease activity in localized scleroderma [9].

Chemical compound and disease context of Scleroderma, Localized


Biological context of Scleroderma, Localized


Anatomical context of Scleroderma, Localized


Gene context of Scleroderma, Localized


Analytical, diagnostic and therapeutic context of Scleroderma, Localized


  1. Antinuclear antibodies in localized scleroderma. Takehara, K., Moroi, Y., Nakabayashi, Y., Ishibashi, Y. Arthritis Rheum. (1983) [Pubmed]
  2. Localized and systemic scleroderma show different histological responses to methotrexate therapy. Seyger, M.M., van den Hoogen, F.H., van Vlijmen-Willems, I.M., van de Kerkhof, P.C., de Jong, E.M. J. Pathol. (2001) [Pubmed]
  3. Lichen sclerosus et atrophicus, morphea, and coexistence of both diseases. Histological studies using lectins. Shono, S., Imura, M., Ota, M., Osaku, A., Shinomiya, S., Toda, K. Archives of dermatology. (1991) [Pubmed]
  4. Detection of Borrelia burgdorferi DNA (B garinii or B afzelii) in morphea and lichen sclerosus et atrophicus tissues of German and Japanese but not of US patients. Fujiwara, H., Fujiwara, K., Hashimoto, K., Mehregan, A.H., Schaumburg-Lever, G., Lange, R., Schempp, C., Gollnick, H. Archives of dermatology. (1997) [Pubmed]
  5. Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine. Boehler, A., Vogt, P., Speich, R., Weder, W., Russi, E.W. Eur. Respir. J. (1996) [Pubmed]
  6. Anti-DNA topoisomerase IIalpha autoantibodies in localized scleroderma. Hayakawa, I., Hasegawa, M., Takehara, K., Sato, S. Arthritis Rheum. (2004) [Pubmed]
  7. Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin 1, in patients with localized scleroderma. Arnett, F.C., Tan, F.K., Uziel, Y., Laxer, R.M., Krafchik, B.R., Antohi, S., Bona, C. Arthritis Rheum. (1999) [Pubmed]
  8. Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon. Higley, H., Persichitte, K., Chu, S., Waegell, W., Vancheeswaran, R., Black, C. Arthritis Rheum. (1994) [Pubmed]
  9. Serum levels of soluble interleukin-2 receptor. A marker of disease activity in localized scleroderma. Uziel, Y., Krafchik, B.R., Feldman, B., Silverman, E.D., Rubin, L.A., Laxer, R.M. Arthritis Rheum. (1994) [Pubmed]
  10. No evidence for Borrelia burgdorferi-specific DNA in lesions of localized scleroderma. Wienecke, R., Schlüpen, E.M., Zöchling, N., Neubert, U., Meurer, M., Volkenandt, M. J. Invest. Dermatol. (1995) [Pubmed]
  11. Influence of 5-aminolevulinic acid and red light on collagen metabolism of human dermal fibroblasts. Karrer, S., Bosserhoff, A.K., Weiderer, P., Landthaler, M., Szeimies, R.M. J. Invest. Dermatol. (2003) [Pubmed]
  12. Effectiveness of topical calcitriol for localized scleroderma. Koeger, A.C., Rozenberg, S., Fautrel, B. J. Rheumatol. (1999) [Pubmed]
  13. Topical calcipotriene for morphea/linear scleroderma. Cunningham, B.B., Landells, I.D., Langman, C., Sailer, D.E., Paller, A.S. J. Am. Acad. Dermatol. (1998) [Pubmed]
  14. Autoantibodies to C-reactive protein (CRP) and other acute-phase proteins in systemic autoimmune diseases. Bell, S.A., Faust, H., Schmid, A., Meurer, M. Clin. Exp. Immunol. (1998) [Pubmed]
  15. Stimulated expression of decorin and the decorin gene in fibroblasts cultured from patients with localized scleroderma. Izumi, T., Tajima, S., Nishikawa, T. Arch. Dermatol. Res. (1995) [Pubmed]
  16. Localized scleroderma after exposure to organic solvents. Czirják, L., Pócs, E., Szegedi, G. Dermatology (Basel) (1994) [Pubmed]
  17. HLA-antigen frequencies in patients with progressive systemic sclerosis and morphea. Kühnl, P., Sibrowski, W., Kalmar, G., Holzmann, H., Sollberg, S., Böhm, B.O. Beiträge zur Infusionstherapie = Contributions to infusion therapy. (1990) [Pubmed]
  18. Fibronectin. Localization in normal human skin, granulation tissue, hypertrophic scar, mature scar, progressive systemic sclerotic skin, and other fibrosing dermatoses. Nagata, H., Ueki, H., Moriguchi, T. Archives of dermatology. (1985) [Pubmed]
  19. Vitamin K1-induced localized scleroderma (morphea) with linear deposition of IgA in the basement membrane zone. Alonso-Llamazares, J., Ahmed, I. J. Am. Acad. Dermatol. (1998) [Pubmed]
  20. VCAM-1 expression on endothelium in lesions from cutaneous lupus erythematosus is increased compared with systemic and localized scleroderma. Jones, S.M., Mathew, C.M., Dixey, J., Lovell, C.R., McHugh, N.J. Br. J. Dermatol. (1996) [Pubmed]
  21. Antibodies to the Borrelia burgdorferi flagellum in patients with scleroderma, granuloma annulare and porphyria cutanea tarda. Halkier-Sørensen, L., Kragballe, K., Hansen, K. Acta Derm. Venereol. (1989) [Pubmed]
  22. Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma. Ihn, H., Sato, S., Fujimoto, M., Kikuchi, K., Takehara, K. Arch. Dermatol. Res. (1995) [Pubmed]
  23. Distribution of transforming growth factor-beta isoforms TGF-beta 1, TGF-beta 2 and TGF-beta 3 and vascular endothelial growth factor in vulvar lichen sclerosus. Farrell, A.M., Dean, D., Charnock, M., Wojnarowska, F. The Journal of reproductive medicine. (2001) [Pubmed]
  24. Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma. Hasegawa, M., Sato, S., Nagaoka, T., Fujimoto, M., Takehara, K. Dermatology (Basel) (2003) [Pubmed]
  25. Circulating levels of soluble CD30 are increased in patients with localized scleroderma and correlated with serological and clinical features of the disease. Ihn, H., Yazawa, N., Kubo, M., Yamane, K., Sato, S., Fujimoto, M., Kikuchi, K., Soma, Y., Tamaki, K. J. Rheumatol. (2000) [Pubmed]
  26. Treatment of severe localized scleroderma by plasmapheresis--report of three cases. Wach, F., Ullrich, H., Schmitz, G., Landthaler, M., Hein, R. Br. J. Dermatol. (1995) [Pubmed]
  27. Morphea after silicone gel breast implantation for cosmetic reasons in an HLA-B8, DR3-positive woman. Di Lorenzo, G., Mansueto, P., Melluso, M., Sangiorgi, G.B., Cigna, D., Candore, G., Caruso, C. Int. Arch. Allergy Immunol. (1997) [Pubmed]
  28. Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea. Kreuter, A., Gambichler, T., Avermaete, A., Jansen, T., Hoffmann, M., Hoffmann, K., Altmeyer, P., von Kobyletzki, G., Bacharach-Buhles, M. Pediatric dermatology. (2001) [Pubmed]
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