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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of tilorone hydrochloride on the lymphoid and interferon responses of athymic mice.

Nude athymic mice, which lack T-lymphocytes and are unable to mount a cellular immune response, failed to develop the lymphopenia so characteristically produced by a 100 mg/kg oral dose of tilorone hydrochloride in normal mice. The antiviral activity detected in athymic mice 18 hr after a 150 mg/kg oral dose of tilorone was significant, although somewhat less than that found in treated normal mice. These findings suggest that tilorone hydrochloride has a specific effect on T-lymphocytes that accounts for its effect on cellular immunity, but that its antiviral activity is not primarily mediated by T-lymphocytes.[1]

References

  1. Effect of tilorone hydrochloride on the lymphoid and interferon responses of athymic mice. Gibson, J.P., Megel, H., Camyre, K.P., Michael, J.G. Proc. Soc. Exp. Biol. Med. (1976) [Pubmed]
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