The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lymphopenia


Psychiatry related information on Lymphopenia


High impact information on Lymphopenia

  • SIRT6-deficient mice are small and at 2-3 weeks of age develop abnormalities that include profound lymphopenia, loss of subcutaneous fat, lordokyphosis, and severe metabolic defects, eventually dying at about 4 weeks [8].
  • Here we describe five patients with growth retardation, microcephaly, and immunodeficiency characterized by a profound T+B lymphocytopenia [9].
  • Lymphopenia developed in 32 of 56 patients treated with 2 mg of azathioprine per kilogram per day for more than two years [10].
  • Mouse studies showed that IL-2 therapy induced expansion of existent T(reg) cells in normal hosts, and IL-2-induced T(reg) cell expansion was further augmented by lymphopenia [11].
  • DOCK2-deficient mice (DOCK2-/-) exhibited migration defects of T and B lymphocytes, but not of monocytes, in response to chemokines, resulting in several abnormalities including T lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells [12].

Chemical compound and disease context of Lymphopenia

  • Genetic deficiencies in the purine catabolic enzyme adenosine deaminase (ADA) in humans results primarily in a severe lymphopenia and immunodeficiency that can lead to the death of affected individuals early in life [13].
  • Additionally, ipriflavone induces lymphocytopenia in a significant number of women [14].
  • Deoxyadenosine has been implicated as the toxic metabolite causing profound lymphopenia in immunodeficient children with a genetic deficiency of adenosine deaminase (ADA), and in adults treated with the potent ADA inhibitor deoxycoformycin [15].
  • These elevated concentrations of adenosine, deoxyadenosine, and dATP are similar to those we observed in another older adenosine deaminase-deficient patient and may explain the impaired immune function and lymphopenia seen at birth [16].
  • These results indicate that neurogenic stimuli from the surgical area, probably through their influence on adrenal hormones (cortisol and adrenaline), are the main mediators of postoperative lymphopenia and are partly responsible for postoperative granulocytosis [17].
  • The presence of lymphopenia at diagnosis and at baseline and higher levels of serum creatinine and C-reactive protein at baseline were positively associated with progression of carotid IMT (P=0.006, P=0.043, P=0.037, and P=0.049, respectively) [18].
  • Inhibition of tumor Gal-1 with either shRNA or thiodigalactoside ablated radiotherapy-induced lymphopenia [19].

Biological context of Lymphopenia


Anatomical context of Lymphopenia

  • IgG cell-associating antilymphocyte antibodies present in SLE sera may cause T cell disturbances in vivo and may be related to the lymphocytopenia present in SLE patients [24].
  • Four hundred milligrams of intravenous hydrocortisone administered 24 hr after infusion of labeled cells caused a profound but transient lymphocytopenia which was maximal at 4 hr with return of lymphocyte counts to normal by 24 hr after injection [25].
  • Neutrophilia and lymphopenia were not affected by anti-TNF, whereas neutrophil degranulation, as measured by the plasma concentrations of elastase-alpha 1-antitrypsin complexes, was only slightly reduced (peak levels after endotoxin alone 31.0 +/- 3.4 ng/mL, versus 25.5 +/- 3.4 ng/mL after endotoxin with anti-TNF; P < .05) [26].
  • Conversely, Hoxa9(-/-) mice displayed marked lymphopenia and substantial reductions of common lymphoid progenitors (CLPs) and lymphoid precursors, in addition to significant reductions of common myeloid progenitors (CMPs) and granulocyte/monocyte progenitors (GMPs) [27].
  • Despite high IL-18 elevation, in vitro NK-cell cytotoxicity was severely impaired in HPS patients, in part due to NK-cell lymphopenia that was observed in a majority of patients but also secondary to an intrinsic NK-cell functional deficiency [28].

Gene context of Lymphopenia


Analytical, diagnostic and therapeutic context of Lymphopenia


  1. Adenosine deaminase deficiency with normal immune function. An acidic enzyme mutation. Daddona, P.E., Mitchell, B.S., Meuwissen, H.J., Davidson, B.L., Wilson, J.M., Koller, C.A. J. Clin. Invest. (1983) [Pubmed]
  2. CD4 lymphocytopenia without HIV in patient with cryptococcal infection. Jowitt, S.N., Love, E.M., Yin, J.A., Pumphrey, R.S. Lancet (1991) [Pubmed]
  3. Opportunistic infections and CD4 lymphocytopenia with interferon treatment in HIV-1 infected patients. Pesce, A., Taillan, B., Rosenthal, E., Garnier, G., Vinti, H., Dujardin, P., Cassuto, J.P. Lancet (1993) [Pubmed]
  4. Incremental value of the leukocyte differential and the rapid creatine kinase-MB isoenzyme for the early diagnosis of myocardial infarction. Thomson, S.P., Gibbons, R.J., Smars, P.A., Suman, V.J., Pierre, R.V., Santrach, P.J., Jiang, N.S. Ann. Intern. Med. (1995) [Pubmed]
  5. Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Nakayama, K., Nakayama, K., Negishi, I., Kuida, K., Sawa, H., Loh, D.Y. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Lymphopenia in primary degenerative dementia. Tollefson, G.D., Godes, M., Warren, J.B., Haus, E., Luxenberg, M., Garvey, M. Journal of psychiatric research. (1989) [Pubmed]
  7. Asymptomatic oral Candida albicans carriage in HIV-infection: frequency and predisposing factors. Fetter, A., Partisani, M., Koenig, H., Kremer, M., Lang, J.M. J. Oral Pathol. Med. (1993) [Pubmed]
  8. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Mostoslavsky, R., Chua, K.F., Lombard, D.B., Pang, W.W., Fischer, M.R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M.M., Mills, K.D., Patel, P., Hsu, J.T., Hong, A.L., Ford, E., Cheng, H.L., Kennedy, C., Nunez, N., Bronson, R., Frendewey, D., Auerbach, W., Valenzuela, D., Karow, M., Hottiger, M.O., Hursting, S., Barrett, J.C., Guarente, L., Mulligan, R., Demple, B., Yancopoulos, G.D., Alt, F.W. Cell (2006) [Pubmed]
  9. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Buck, D., Malivert, L., de Chasseval, R., Barraud, A., Fondanèche, M.C., Sanal, O., Plebani, A., Stéphan, J.L., Hufnagel, M., le Deist, F., Fischer, A., Durandy, A., de Villartay, J.P., Revy, P. Cell (2006) [Pubmed]
  10. Azathioprine for long-term maintenance of remission in autoimmune hepatitis. Johnson, P.J., McFarlane, I.G., Williams, R. N. Engl. J. Med. (1995) [Pubmed]
  11. Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Zhang, H., Chua, K.S., Guimond, M., Kapoor, V., Brown, M.V., Fleisher, T.A., Long, L.M., Bernstein, D., Hill, B.J., Douek, D.C., Berzofsky, J.A., Carter, C.S., Read, E.J., Helman, L.J., Mackall, C.L. Nat. Med. (2005) [Pubmed]
  12. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Fukui, Y., Hashimoto, O., Sanui, T., Oono, T., Koga, H., Abe, M., Inayoshi, A., Noda, M., Oike, M., Shirai, T., Sasazuki, T. Nature (2001) [Pubmed]
  13. Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation. Blackburn, M.R., Kellems, R.E. Adv. Immunol. (2005) [Pubmed]
  14. Ipriflavone in the treatment of postmenopausal osteoporosis: a randomized controlled trial. Alexandersen, P., Toussaint, A., Christiansen, C., Devogelaer, J.P., Roux, C., Fechtenbaum, J., Gennari, C., Reginster, J.Y. JAMA (2001) [Pubmed]
  15. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. Seto, S., Carrera, C.J., Kubota, M., Wasson, D.B., Carson, D.A. J. Clin. Invest. (1985) [Pubmed]
  16. Plasma deoxyadenosine, adenosine, and erythrocyte deoxyATP are elevated at birth in an adenosine deaminase-deficient child. Hirschhorn, R., Roegner, V., Rubinstein, A., Papageorgiou, P. J. Clin. Invest. (1980) [Pubmed]
  17. Prevention of postoperative lymphopenia and granulocytosis by epidural analgesia. Rem, J., Brandt, M.R., Kehlet, H. Lancet (1980) [Pubmed]
  18. Lymphopenia is a risk factor in the progression of carotid intima-media thickness in juvenile-onset systemic lupus erythematosus. Huang, Y.L., Chung, H.T., Chang, C.J., Yeh, K.W., Chen, L.C., Huang, J.L. Arthritis Rheum. (2009) [Pubmed]
  19. Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response. Kuo, P., Bratman, S.V., Shultz, D.B., von Eyben, R., Chan, C., Wang, Z., Say, C., Gupta, A., Loo, B.W., Giaccia, A.J., Koong, A.C., Diehn, M., Le, Q.T. Clin. Cancer Res. (2014) [Pubmed]
  20. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Gavin, M.A., Clarke, S.R., Negrou, E., Gallegos, A., Rudensky, A. Nat. Immunol. (2002) [Pubmed]
  21. Characterization of marginal zone B cell precursors. Srivastava, B., Quinn, W.J., Hazard, K., Erikson, J., Allman, D. J. Exp. Med. (2005) [Pubmed]
  22. Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice. MacKenzie, K.L., Dolnikov, A., Millington, M., Shounan, Y., Symonds, G. Blood (1999) [Pubmed]
  23. Didanosine plus stavudine with or without hydroxyurea in HIV-1-infected patients: 1 year follow-up. Swiss HIV Cohort Study. Rutschmann, O.T., Opravil, M., Iten, A., Malinverni, R., Vernazza, P.L., Bucher, H., Bernasconi, E., Perrin, L.H., Yerly, S., Hirschel, B. Antivir. Ther. (Lond.) (1998) [Pubmed]
  24. T lymphocyte interaction with immunoglobulin G antibody in systemic lupus erythematosus. Okudaira, K., Searles, R.P., Tanimoto, K., Horiuchi, Y., Williams, R.C. J. Clin. Invest. (1982) [Pubmed]
  25. The effect of Hydrocortisone on the kinetics of normal human lymphocytes. Fauci, A.S., Dale, D.C. Blood (1975) [Pubmed]
  26. Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees. van der Poll, T., Levi, M., van Deventer, S.J., ten Cate, H., Haagmans, B.L., Biemond, B.J., Büller, H.R., Hack, C.E., ten Cate, J.W. Blood (1994) [Pubmed]
  27. Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. So, C.W., Karsunky, H., Wong, P., Weissman, I.L., Cleary, M.L. Blood (2004) [Pubmed]
  28. Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Mazodier, K., Marin, V., Novick, D., Farnarier, C., Robitail, S., Schleinitz, N., Veit, V., Paul, P., Rubinstein, M., Dinarello, C.A., Harlé, J.R., Kaplanski, G. Blood (2005) [Pubmed]
  29. Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Coultas, L., Bouillet, P., Stanley, E.G., Brodnicki, T.C., Adams, J.M., Strasser, A. Mol. Cell. Biol. (2004) [Pubmed]
  30. Association of immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita. Knudson, M., Kulkarni, S., Ballas, Z.K., Bessler, M., Goldman, F. Blood (2005) [Pubmed]
  31. Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosis factor-alpha-induced changes in circulating numbers of neutrophils and lymphocytes. Ulich, T.R., del Castillo, J., Keys, M., Granger, G.A., Ni, R.X. J. Immunol. (1987) [Pubmed]
  32. The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Hornum, L., Rømer, J., Markholst, H. Diabetes (2002) [Pubmed]
  33. Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. Allende, M.L., Sasaki, T., Kawai, H., Olivera, A., Mi, Y., van Echten-Deckert, G., Hajdu, R., Rosenbach, M., Keohane, C.A., Mandala, S., Spiegel, S., Proia, R.L. J. Biol. Chem. (2004) [Pubmed]
  34. In vivo hematologic effects of recombinant human macrophage colony-stimulating factor. Ulich, T.R., del Castillo, J., Watson, L.R., Yin, S.M., Garnick, M.B. Blood (1990) [Pubmed]
  35. In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice. Blazar, B.R., Taylor, P.A., Linsley, P.S., Vallera, D.A. Blood (1994) [Pubmed]
  36. Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2. Takada, T., Iida, K., Moss, J. J. Biol. Chem. (1994) [Pubmed]
  37. Risk factors for CD4 lymphopenia in patients treated with a tenofovir/didanosine high dose-containing highly active antiretroviral therapy regimen. Lacombe, K., Pacanowski, J., Meynard, J.L., Trylesinski, A., Girard, P.M. AIDS (2005) [Pubmed]
WikiGenes - Universities