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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Genomic structure and chromosomal mapping of the mouse hic-5 gene that encodes a focal adhesion protein.

The hic-5 gene encodes a focal adhesion protein that has striking similarity to paxillin. Genomic clones of the mouse hic-5 gene were isolated, and included 10 exons that covered the whole mouse mRNA sequence. Comparison of the sequence with those in the expressed sequence tag database suggested that the hic-5 gene contained an extra exon (named exon 1') located about 1kb upstream of exon 1, and mouse cells seemed to express two alternatively spliced forms of mRNA. All the exon-intron boundaries followed the GT/AG rule. Physical mapping and fluorescent in situ hybridization analysis indicated that the hic-5 gene is located on mouse chromosome 7, 60. 0cM from the centromere.[1]

References

  1. Genomic structure and chromosomal mapping of the mouse hic-5 gene that encodes a focal adhesion protein. Mashimo, J., Shibanuma, M., Satoh, H., Chida, K., Nose, K. Gene (2000) [Pubmed]
 
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