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Gene Review

Pxn  -  paxillin

Mus musculus

Synonyms: AW108311, AW123232, Pax, Paxillin
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Disease relevance of Pxn


High impact information on Pxn


Chemical compound and disease context of Pxn


Biological context of Pxn


Anatomical context of Pxn


Associations of Pxn with chemical compounds


Physical interactions of Pxn


Enzymatic interactions of Pxn


Regulatory relationships of Pxn


Other interactions of Pxn


Analytical, diagnostic and therapeutic context of Pxn

  • Western blot analyses of degradation products of overexpressed green fluorescence protein-tagged paxillin and site-specific mutants demonstrated that Asp-102 and Asp-301 were early caspase cleavage sites, and Asp-5, Asp-146, Asp-165, and Asp-222 were late cleavage sites [26].
  • The ability of ARF1 to regulate paxillin recruitment to focal adhesions was confirmed by microinjection of Q71LARF1 and Delta17ARF1 into intact cells [30].
  • These proteins were identified as paxillin and FAK, respectively, by immunoprecipitation with anti-paxillin and anti-FAK antibodies [31].
  • Immunofluorescence analysis of echistatin treated cells showed the concomitant disappearance of both paxillin and pp125FAK from focal adhesions [32].
  • Tracheal constriction studies demonstrate that the level of constriction is the same with knockout of the beta(1)-subunit and BK channel block with paxillin, indicating that BK channels contribute little to airway relaxation in the absence of the beta(1)-subunit [33].


  1. Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells. Ku, H., Meier, K.E. J. Biol. Chem. (2000) [Pubmed]
  2. Sustained activation of MAPK/ERKs signaling pathway in cystic kidneys from bcl-2 -/- mice. Sorenson, C.M., Sheibani, N. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  3. Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling. Melendez, J., Welch, S., Schaefer, E., Moravec, C.S., Avraham, S., Avraham, H., Sussman, M.A. J. Biol. Chem. (2002) [Pubmed]
  4. Protein phosphatase-2A modulates the serine and tyrosine phosphorylation of paxillin in Lewis lung carcinoma tumor variants. Jackson, J.L., Young, M.R. Clin. Exp. Metastasis (2002) [Pubmed]
  5. Pasteurella multocida toxin, a potent intracellularly acting mitogen, induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells. Lacerda, H.M., Lax, A.J., Rozengurt, E. J. Biol. Chem. (1996) [Pubmed]
  6. Periodic lamellipodial contractions correlate with rearward actin waves. Giannone, G., Dubin-Thaler, B.J., Döbereiner, H.G., Kieffer, N., Bresnick, A.R., Sheetz, M.P. Cell (2004) [Pubmed]
  7. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Nobes, C.D., Hall, A. Cell (1995) [Pubmed]
  8. Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Sakai, T., Li, S., Docheva, D., Grashoff, C., Sakai, K., Kostka, G., Braun, A., Pfeifer, A., Yurchenco, P.D., Fässler, R. Genes Dev. (2003) [Pubmed]
  9. Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. Ishibe, S., Joly, D., Liu, Z.X., Cantley, L.G. Mol. Cell (2004) [Pubmed]
  10. Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. Ishibe, S., Joly, D., Zhu, X., Cantley, L.G. Mol. Cell (2003) [Pubmed]
  11. Guanosine 5'-3-O-(thio)triphosphate stimulates tyrosine phosphorylation of p125FAK and paxillin in permeabilized Swiss 3T3 cells. Role of p21rho. Seckl, M.J., Morii, N., Narumiya, S., Rozengurt, E. J. Biol. Chem. (1995) [Pubmed]
  12. Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants. Jackson, J.L., Young, M.R. Clin. Exp. Metastasis (2003) [Pubmed]
  13. Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. Subauste, M.C., Pertz, O., Adamson, E.D., Turner, C.E., Junger, S., Hahn, K.M. J. Cell Biol. (2004) [Pubmed]
  14. EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118. Vindis, C., Teli, T., Cerretti, D.P., Turner, C.E., Huynh-Do, U. J. Biol. Chem. (2004) [Pubmed]
  15. Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase. Wade, R., Bohl, J., Vande Pol, S. Oncogene (2002) [Pubmed]
  16. The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Hayashi, I., Vuori, K., Liddington, R.C. Nat. Struct. Biol. (2002) [Pubmed]
  17. Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase. Nishiya, N., Tachibana, K., Shibanuma, M., Mashimo, J.I., Nose, K. Mol. Cell. Biol. (2001) [Pubmed]
  18. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Hagel, M., George, E.L., Kim, A., Tamimi, R., Opitz, S.L., Turner, C.E., Imamoto, A., Thomas, S.M. Mol. Cell. Biol. (2002) [Pubmed]
  19. The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells. Salgia, R., Avraham, S., Pisick, E., Li, J.L., Raja, S., Greenfield, E.A., Sattler, M., Avraham, H., Griffin, J.D. J. Biol. Chem. (1996) [Pubmed]
  20. Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway. Woodrow, M.A., Woods, D., Cherwinski, H.M., Stokoe, D., McMahon, M. Exp. Cell Res. (2003) [Pubmed]
  21. Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS). Sinnett-Smith, J., Lunn, J.A., Leopoldt, D., Rozengurt, E. Exp. Cell Res. (2001) [Pubmed]
  22. Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinase. Cooley, M.A., Broome, J.M., Ohngemach, C., Romer, L.H., Schaller, M.D. Mol. Biol. Cell (2000) [Pubmed]
  23. Adenovirus-mediated overexpression of C-terminal Src kinase (Csk) in type I astrocytes interferes with cell spreading and attachment to fibronectin. Correlation with tyrosine phosphorylations of paxillin and FAK. Takayama, Y., Tanaka, S., Nagai, K., Okada, M. J. Biol. Chem. (1999) [Pubmed]
  24. Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Brown, M.C., Cary, L.A., Jamieson, J.S., Cooper, J.A., Turner, C.E. Mol. Biol. Cell (2005) [Pubmed]
  25. Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells. Salazar, E.P., Hunger-Glaser, I., Rozengurt, E. J. Cell. Physiol. (2003) [Pubmed]
  26. Linkage of caspase-mediated degradation of paxillin to apoptosis in Ba/F3 murine pro-B lymphocytes. Chay, K.O., Park, S.S., Mushinski, J.F. J. Biol. Chem. (2002) [Pubmed]
  27. Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src. Nakaigawa, N., Weirich, G., Schmidt, L., Zbar, B. Oncogene (2000) [Pubmed]
  28. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Kawada, M., Amemiya, M., Ishizuka, M., Takeuchi, T. Biochim. Biophys. Acta (1999) [Pubmed]
  29. Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. Shen, T.L., Guan, J.L. FEBS Lett. (2001) [Pubmed]
  30. ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts. Norman, J.C., Jones, D., Barry, S.T., Holt, M.R., Cockcroft, S., Critchley, D.R. J. Cell Biol. (1998) [Pubmed]
  31. Clustering of cell surface (beta)1,4-galactosyltransferase I induces transient tyrosine phosphorylation of focal adhesion kinase and loss of stress fibers. Wassler, M.J., Shur, B.D. J. Cell. Sci. (2000) [Pubmed]
  32. Echistatin inhibits pp125FAK autophosphorylation, paxillin phosphorylation and pp125FAK-paxillin interaction in fibronectin-adherent melanoma cells. Della Morte, R., Squillacioti, C., Garbi, C., Derkinderen, P., Belisario, M.A., Girault, J.A., Di Natale, P., Nitsch, L., Staiano, N. Eur. J. Biochem. (2000) [Pubmed]
  33. BK channel beta1-subunit regulation of calcium handling and constriction in tracheal smooth muscle. Semenov, I., Wang, B., Herlihy, J.T., Brenner, R. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
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