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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL.

TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete. To explain the residual photoresponse that remains in the trp mutant, a third TRP-related subunit has previously been proposed to function with TRPL. Here, we identify such a subunit, TRPgamma. We show that TRPgamma is highly enriched in photoreceptor cells and preferentially heteromultimerizes with TRPL in vitro and in vivo. The N-terminal domain of TRPgamma dominantly suppressed the TRPL-dependent photoresponse, indicating that TRPgamma-TRPL heteromultimers contribute to the photoresponse. While TRPL and TRPgamma homomultimers are constitutively active, we demonstrate that TRPL-TRPgamma heteromultimers form a regulated phospholipase C- (PLC-) stimulated channel.[1]


  1. TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Xu, X.Z., Chien, F., Butler, A., Salkoff, L., Montell, C. Neuron (2000) [Pubmed]
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