Disease relevance of tryptacin

• The medium relies on the ability of all members of the Proteeae (with the exception of a very few Morganella morganii strains) to produce a dark brown pigment in medium containing DL-tryptophan [1].
• Synthesis of DL: -tryptophan by modified broad specificity amino acid racemase from Pseudomonas putida IFO 12996 [2].

Psychiatry related information on tryptacin

• We have extended earlier experiments on the radiolysis of DL-tryptophan using 32 p beta-radiation to longer reaction times, observing complete destruction of the tryptophan by secondary, non-radiolytic processes [3].

High impact information on tryptacin

• Magnetic circular dichroism studies of indole, DL-tryptophan, and serotonin [4].
• BSA with a degree of multilayer binding of 4 specifically recognized L-tryptophan with a separation factor of 6.6 during permeation by a mobile phase (Tris-HC1 buffer) injected with a racemic solution of DL-tryptophan through the BSA-multilayered porous membrane [5].
• Chiral separation of DL-tryptophan using porous membranes containing multilayered bovine serum albumin crosslinked with glutaraldehyde [6].
• The concentration of l-tryptophan was two to three times higher than that of dl-tryptophan and selenomethionine in the pancreas at the earlier times, but after 1 hour they became equivalent [7].
• Trp-P-1, a DL-tryptophan pyrolysis product, was previously known for its mutagenic and hepato-carcinogenic properties and for inducing nucleolar damage in adult rat hepatocytes in primary culture [8].

Biological context of tryptacin

• 4. DL-Tryptophan itself did not provide a significant contribution of substrate to the total rate of lipogenesis [9].
• The synthesis of tryptamine via DL-tryptophan decarboxylation in cyclohexanol, in the presence of tetraline oxidation products as the catalyst, was described as well [10].

Associations of tryptacin with other chemical compounds

• The run buffer is pH 7.0, 20 mM sodium phosphate, 20 mM sodium dodecyl sulfate, with 10% isopropanol; the internal standard is dl-tryptophan [11].
• Chiral stationary phases obtained by immobilization of HSA on [C8] and [C18] reversed-phases and on poly(1-vinylimidazole)-coated silica were tested to resolve DL-tryptophan, N-benzoyl-DL-phenylalanine, RS-oxazepam and RS-warfarin racemic mixtures [12].
• Bypassing the requirement for tryptophan degradation by the administration of L-kynurenine resulted in amelioration of arthritis [13].
• AMT PET/CT may be a clinically useful molecular imaging method for personalized cancer treatment by identifying and monitoring patients who have increased tumor tryptophan metabolism and are potentially sensitive to immunopharmacotherapy with indoleamine 2,3-dioxygenase inhibitors [14].

Analytical, diagnostic and therapeutic context of tryptacin

• To investigate the 'enantiomer-differentiating' action of the microorganisms colonizing a phosphate-buffered DL-tryptophan solution, a novel chiral high-performance liquid chromatographic (HPLC) arrangement was developed and established [15].
• Chiral stationary phases obtained by immobilization of human serum albumin (HSA) on various polymer-coated silicas were tested to resolve DL-tryptophan, DL-NBP, RS-oxazepam and RS-warfarin racemic mixtures [16].

References