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Chemical Compound Review

Htrp     2-amino-3-(1H-indol-3- yl)propanoic acid

Synonyms: D-Trypophan, DL-Trytophan, L-Trytophane, DL-Tryptophan, DL-Trytophane, ...
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Disease relevance of tryptacin

  • The medium relies on the ability of all members of the Proteeae (with the exception of a very few Morganella morganii strains) to produce a dark brown pigment in medium containing DL-tryptophan [1].
  • Synthesis of DL: -tryptophan by modified broad specificity amino acid racemase from Pseudomonas putida IFO 12996 [2].

Psychiatry related information on tryptacin


High impact information on tryptacin


Biological context of tryptacin


Associations of tryptacin with other chemical compounds


Analytical, diagnostic and therapeutic context of tryptacin

  • To investigate the 'enantiomer-differentiating' action of the microorganisms colonizing a phosphate-buffered DL-tryptophan solution, a novel chiral high-performance liquid chromatographic (HPLC) arrangement was developed and established [15].
  • Chiral stationary phases obtained by immobilization of human serum albumin (HSA) on various polymer-coated silicas were tested to resolve DL-tryptophan, DL-NBP, RS-oxazepam and RS-warfarin racemic mixtures [16].


  1. Selective and differential medium for the primary isolation of members of the Proteeae. Hawkey, P.M., McCormick, A., Simpson, R.A. J. Clin. Microbiol. (1986) [Pubmed]
  2. Synthesis of DL: -tryptophan by modified broad specificity amino acid racemase from Pseudomonas putida IFO 12996. Kino, K., Sato, M., Yoneyama, M., Kirimura, K. Appl. Microbiol. Biotechnol. (2007) [Pubmed]
  3. The radiolysis of tryptophan and leucine with 32P beta-radiation. Blair, N.E., Bonner, W.A. J. Mol. Evol. (1980) [Pubmed]
  4. Magnetic circular dichroism studies of indole, DL-tryptophan, and serotonin. Sprinkel, F.M., Shillady, D.D., Strickland, R.W. J. Am. Chem. Soc. (1975) [Pubmed]
  5. High resolution of DL-tryptophan at high flow rates using a bovine serum albumin-multilayered porous hollow-fiber membrane. Nakamura, M., Kiyohara, S., Saito, K., Sugita, K., Sugo, T. Anal. Chem. (1999) [Pubmed]
  6. Chiral separation of DL-tryptophan using porous membranes containing multilayered bovine serum albumin crosslinked with glutaraldehyde. Nakamura, M., Kiyohara, S., Saito, K., Sugita, K., Sugo, T. Journal of chromatography. A. (1998) [Pubmed]
  7. Biodistribution studies of labeled tryptophan: a potential pancreas-scanning agent. Matolo, N.M., Stadalnik, R.C., Krohn, K.A. Am. J. Surg. (1978) [Pubmed]
  8. Early cellular effects of Trp-P-1 on adult rat hepatocytes in primary culture. Thybaud-Lambay, V., Martin, M., Decloitre, F. Chem. Biol. Interact. (1985) [Pubmed]
  9. Tryptophan and the control of triglyceride and carbohydrate metabolism in the rat. Fears, R., Murrell, E.A. Br. J. Nutr. (1980) [Pubmed]
  10. Synthesis of N-nicotinoyl-tryptamine (tryptamide). Eckstein, M., Misztal, S., Terczyńska, A., Sienkiewicz, B., Roszkowski, A., Adamus, M. Polish journal of pharmacology and pharmacy. (1987) [Pubmed]
  11. A method for the determination of minoxidil in hair-regrowth formulations by micellar electrokinetic capillary chromatography. Gibson, G., Ramstad, T., Mills, K.A., Dunn, M.J. Farmaco (2005) [Pubmed]
  12. Structural changes of human serum albumin immobilized on chromatographic supports: a high-performance liquid chromatography and Fourier-transform infrared spectroscopy study. Millot, M.C., Servagent-Noinville, S., Taleb, N.L., Baron, M.H., Revault, M., Sébille, B. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
  13. Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis. Criado, G., Simelyte, E., Inglis, J.J., Essex, D., Williams, R.O. Arthritis Rheum. (2009) [Pubmed]
  14. Quantification of tryptophan transport and metabolism in lung tumors using PET. Juhász, C., Muzik, O., Lu, X., Jahania, M.S., Soubani, A.O., Khalaf, M., Peng, F., Mangner, T.J., Chakraborty, P.K., Chugani, D.C. J. Nucl. Med. (2009) [Pubmed]
  15. A simple chiral high-performance liquid chromatographic method to study the enantiomer-differentiating action of microorganisms. An assay with DL-tryptophan. Soltés, L., Sébille, B. Biomed. Chromatogr. (1999) [Pubmed]
  16. Binding of human serum albumin to silica particles by means of polymers: a liquid chromatographic study of the selectivity of resulting chiral stationary phases. Millot, M.C., Taleb, N.L., Sebille, B. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2002) [Pubmed]
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