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Gene Review

Trpgamma  -  Transient receptor potential cation...

Drosophila melanogaster

Synonyms: CG5996, DmTRPgamma, Dmel\CG5996, TRPgamma, Transient receptor potential-gamma protein, ...
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Disease relevance of trpgamma


High impact information on trpgamma

  • Studies on visual signal transduction in Drosophila led to the hypothesis that a protein encoded in trp may be a component of CCE channels [2].
  • As well as being a major charge carrier for the light-induced current, Ca2+ influx via the trp-dependent channels appears to be required for refilling Ca2+ stores sensitive to inositol 1,4,5-trisphosphate and for feedback regulation (light adaptation) of the transduction cascade [3].
  • Using genetically targeted PIP2-sensitive inward rectifier channels (Kir2.1) as biosensors, we provide evidence that trp decay reflects depletion of PIP2 [4].
  • We show that TRPgamma is highly enriched in photoreceptor cells and preferentially heteromultimerizes with TRPL in vitro and in vivo [5].
  • The TIM response to a light pulse was attenuated in flies that were mutant for the transient receptor potential (trp) and trp-like (trpl) genes, which are required for calcium conductance in the visual transduction cascade [6].

Biological context of trpgamma

  • Despite the prevalence of store-operated Ca2+ entry, no vertebrate channel responsible for store-operated Ca2+ entry has been reported. trp (transient receptor potential), a Drosophila gene required in phototransduction, encodes the only known candidate for such a channel throughout phylogeny [7].
  • Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels [8].
  • Comparison of the amino acid sequence encoded by this cDNA with entries in the OWL composite protein sequence database reveals greatest sequence similarity with the products of the Drosophila trp and trpl genes [9].
  • Measurement of cytosolic calcium concentrations ([Ca(2+)](i)) in tubule principal cells using an aequorin transgene in trp and trpl mutants showed a reduction in calcium responses in trpl(302) [10].
  • The identification of a protein similar to the trp gene product, yet also able to bind Ca2+/calmodulin, allows for a reinterpretation of the phenotype of the trp mutations and suggests that both genes may encode light-sensitive ion channels [11].

Anatomical context of trpgamma

  • Furthermore, several lines of evidence suggest that the trp gene product TRP is a candidate subunit of the plasma membrane channel that is activated by Ca2+ store depletion [12].
  • Northern blot analysis confirmed that trp, inaC and InaD transcripts were present in RNA isolated from the retina, but not in RNA isolated from brain or thorax [13].
  • It is thus possible that capacitative calcium entry in Xenopus oocytes is mediated by a homologue of trp [14].

Associations of trpgamma with chemical compounds


Other interactions of trpgamma

  • Use of antipeptide polyclonal antibodies for TRP, TRPL, and TRPgamma showed expression of all three channels in type 1 (principal) cells in the tubule main segment [10].

Analytical, diagnostic and therapeutic context of trpgamma


  1. Activation of recombinant trp by thapsigargin in Sf9 insect cells. Vaca, L., Sinkins, W.G., Hu, Y., Kunze, D.L., Schilling, W.P. Am. J. Physiol. (1994) [Pubmed]
  2. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Zhu, X., Jiang, M., Peyton, M., Boulay, G., Hurst, R., Stefani, E., Birnbaumer, L. Cell (1996) [Pubmed]
  3. Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization. Hardie, R.C., Minke, B. Trends Neurosci. (1993) [Pubmed]
  4. Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Hardie, R.C., Raghu, P., Moore, S., Juusola, M., Baines, R.A., Sweeney, S.T. Neuron (2001) [Pubmed]
  5. TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Xu, X.Z., Chien, F., Butler, A., Salkoff, L., Montell, C. Neuron (2000) [Pubmed]
  6. Response of the timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception. Yang, Z., Emerson, M., Su, H.S., Sehgal, A. Neuron (1998) [Pubmed]
  7. TRPC1, a human homolog of a Drosophila store-operated channel. Wes, P.D., Chevesich, J., Jeromin, A., Rosenberg, C., Stetten, G., Montell, C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  8. Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. Tang, J., Lin, Y., Zhang, Z., Tikunova, S., Birnbaumer, L., Zhu, M.X. J. Biol. Chem. (2001) [Pubmed]
  9. Isolation, cloning, and characterisation of a trp homologue from squid (Loligo forbesi) photoreceptor membranes. Monk, P.D., Carne, A., Liu, S.H., Ford, J.W., Keen, J.N., Findlay, J.B. J. Neurochem. (1996) [Pubmed]
  10. Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. MacPherson, M.R., Pollock, V.P., Kean, L., Southall, T.D., Giannakou, M.E., Broderick, K.E., Dow, J.A., Hardie, R.C., Davies, S.A. Genetics (2005) [Pubmed]
  11. Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene. Phillips, A.M., Bull, A., Kelly, L.E. Neuron (1992) [Pubmed]
  12. Role of Drosophila TRP in inositide-mediated Ca2+ entry. Minke, B., Selinger, Z. Mol. Neurobiol. (1996) [Pubmed]
  13. Isolation of genes encoding photoreceptor-specific proteins by immunoscreening with antibodies directed against purified blowfly rhabdoms. Huber, A., Sander, P., Wolfrum, U., Groell, C., Gerdon, G., Paulsen, R. J. Photochem. Photobiol. B, Biol. (1996) [Pubmed]
  14. Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues. Petersen, C.C., Berridge, M.J., Borgese, M.F., Bennett, D.L. Biochem. J. (1995) [Pubmed]
  15. The light response of Drosophila photoreceptors is accompanied by an increase in cellular calcium: effects of specific mutations. Peretz, A., Suss-Toby, E., Rom-Glas, A., Arnon, A., Payne, R., Minke, B. Neuron (1994) [Pubmed]
  16. Functional equivalence of native light-sensitive channels in the Drosophila trp301 mutant and TRPL cation channels expressed in a stably transfected Drosophila cell line. Hardie, R.C., Reuss, H., Lansdell, S.J., Millar, N.S. Cell Calcium (1997) [Pubmed]
  17. Photolysis of caged Ca2+ facilitates and inactivates but does not directly excite light-sensitive channels in Drosophila photoreceptors. Hardie, R.C. J. Neurosci. (1995) [Pubmed]
  18. Receptor-induced activation of Drosophila TRP gamma by polyunsaturated fatty acids. Jörs, S., Kazanski, V., Foik, A., Krautwurst, D., Harteneck, C. J. Biol. Chem. (2006) [Pubmed]
  19. Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. Zhu, X., Chu, P.B., Peyton, M., Birnbaumer, L. FEBS Lett. (1995) [Pubmed]
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