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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Expression and localization of utrophin in differentiating PC12 cells.

To ascertain the role of utrophin in cultured neuronal cells, we investigated its expression and distribution along the NGF-induced differentiation of PC12 cells grown on different substrata. Utrophin mRNA was measured by RT-PCR assay and utrophin protein was quantified by immunoblot analysis. The distribution of utrophin and beta-dystroglycan was analyzed by confocal microscopy. We demonstrate that utrophin protein was increased 4-fold during differentiation of cells grown laminin. Concomitant with this up-regulation, utrophin was enriched at the growth cones in differentiating cells, where it co-localizes with beta-dystroglycan. These data suggest the presence of a utrophin-beta-dystroglycan complex in PC12 cells that participates in the formation and/or stabilization of the growth cone-extracellular matrix adhesion.[1]


  1. Expression and localization of utrophin in differentiating PC12 cells. Rosas-Vargas, H., Montañez, C., Rendón, A., Mornet, D., García, F., Ceja, V., Cisneros, B. Neuroreport (2000) [Pubmed]
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