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Gene Review

Utrn  -  utrophin

Rattus norvegicus

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Disease relevance of Utrn


High impact information on Utrn


Biological context of Utrn


Anatomical context of Utrn


Associations of Utrn with chemical compounds

  • Its sequence is identical to that of the full-length utrophin, except for the last residue where Cys is replaced by Val [2].
  • Dystrophin and utrophin are known to link the intracellular cytoskeleton to the extracellular matrix via a transmembraneous glycoprotein complex [2].
  • Our results show that utrophin labelling is closely co-localized with that of acetylcholine receptors throughout postnatal maturation. beta-dystroglycan labelling is present at most sites of high acetylcholine receptors density throughout maturation although it often extends beyond the region of highest acetylcholine receptors labelling density [12].
  • Upon binding, laminin interacts with dystroglycan, mobilizes utrophin, and assembles a 'nascent' basement membrane, independent of integrin, that is completed by incorporation of type IV collagen [13].
  • Digoxigenin-labeled cRNA probes complementary to N-terminal, rod-domain, and C-terminal encoding sequences of utrophin were used to differentiate between full-length and short C-terminal isoforms [14].

Physical interactions of Utrn


Other interactions of Utrn


Analytical, diagnostic and therapeutic context of Utrn


  1. An atomic model for actin binding by the CH domains and spectrin-repeat modules of utrophin and dystrophin. Sutherland-Smith, A.J., Moores, C.A., Norwood, F.L., Hatch, V., Craig, R., Kendrick-Jones, J., Lehman, W. J. Mol. Biol. (2003) [Pubmed]
  2. Identification and characterisation of transcript and protein of a new short N-terminal utrophin isoform. Zuellig, R.A., Bornhauser, B.C., Knuesel, I., Heller, F., Fritschy, J.M., Schaub, M.C. J. Cell. Biochem. (2000) [Pubmed]
  3. Dystrophins in neurohypophysial lobe of normal and dehydrated rats: immunolocalization and biochemical characterization. Dorbani-Mamine, L., Stoeckel, M.E., Jancsik, V., Ayad, G., Rendon, A. Neuroreport (1998) [Pubmed]
  4. Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes. Imamura, M., Ozawa, E. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. The Ets transcription factor GABP is required for postsynaptic differentiation in vivo. Briguet, A., Ruegg, M.A. J. Neurosci. (2000) [Pubmed]
  6. Expression of agrin, dystroglycan, and utrophin in normal renal tissue and in experimental glomerulopathies. Raats, C.J., van den Born, J., Bakker, M.A., Oppers-Walgreen, B., Pisa, B.J., Dijkman, H.B., Assmann, K.J., Berden, J.H. Am. J. Pathol. (2000) [Pubmed]
  7. Expression and localization of utrophin in differentiating PC12 cells. Rosas-Vargas, H., Montañez, C., Rendón, A., Mornet, D., García, F., Ceja, V., Cisneros, B. Neuroreport (2000) [Pubmed]
  8. Dystrophin (Xp21), a new phenotype marker of cultured rat aortic myocytes. Lees, D., Fabbrizio, E., Mornet, D., Harricane, M.C., Travo, P. Exp. Cell Res. (1994) [Pubmed]
  9. Characterization of the intermolecular associations of the dystrophin-associated glycoprotein complex in retinal Müller glial cells. Claudepierre, T., Dalloz, C., Mornet, D., Matsumura, K., Sahel, J., Rendon, A. J. Cell. Sci. (2000) [Pubmed]
  10. Neural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscle. Leschziner, A., Moukhles, H., Lindenbaum, M., Gee, S.H., Butterworth, J., Campbell, K.P., Carbonetto, S. J. Neurochem. (2000) [Pubmed]
  11. Immunolocalization of dystrobrevin in the astrocytic endfeet and endothelial cells in the rat cerebellum. Ueda, H., Baba, T., Terada, N., Kato, Y., Fujii, Y., Takayama, I., Mei, X., Ohno, S. Neurosci. Lett. (2000) [Pubmed]
  12. Spatial relationships of utrophin, dystrophin, beta-dystroglycan and beta-spectrin to acetylcholine receptor clusters during postnatal maturation of the rat neuromuscular junction. Bewick, G.S., Young, C., Slater, C.R. J. Neurocytol. (1996) [Pubmed]
  13. Laminin assembles into separate basement membrane and fibrillar matrices in Schwann cells. Tsiper, M.V., Yurchenco, P.D. J. Cell. Sci. (2002) [Pubmed]
  14. Differential expression of utrophin and dystrophin in CNS neurons: an in situ hybridization and immunohistochemical study. Knuesel, I., Bornhauser, B.C., Zuellig, R.A., Heller, F., Schaub, M.C., Fritschy, J.M. J. Comp. Neurol. (2000) [Pubmed]
  15. Dystroglycan in the cerebellum is a laminin alpha 2-chain binding protein at the glial-vascular interface and is expressed in Purkinje cells. Tian, M., Jacobson, C., Gee, S.H., Campbell, K.P., Carbonetto, S., Jucker, M. Eur. J. Neurosci. (1996) [Pubmed]
  16. Dystrophins in developing retina: Dp260 expression correlates with synaptic maturation. Rodius, F., Claudepierre, T., Rosas-Vargas, H., Cisneros, B., Montanez, C., Dreyfus, H., Mornet, D., Rendon, A. Neuroreport (1997) [Pubmed]
  17. Utrophin may be a precursor of dystrophin during skeletal muscle development. Lin, S., Burgunder, J.M. Brain Res. Dev. Brain Res. (2000) [Pubmed]
  18. Utrophin is lacking at the neuromuscular junctions in the extraocular muscles of normal cat: artefact or true? Assadi, M., Müntener, M. Histochem. Cell Biol. (2005) [Pubmed]
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