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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Phylogenetic subgroups of human T cell lymphotropic virus (HTLV) type I in the tax gene and their association with different risks for HTLV-I-associated myelopathy/tropical spastic paraparesis.

The association between human T cell lymphotropic virus (HTLV) type I tax variation and disease outcome was studied. The tax gene was sequenced in 61 patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/ TSP), 55 patients with adult T cell leukemia, and 62 healthy carriers (HCs). Phylogenetic analysis revealed 2 tax gene subgroups that are related on the basis of the long terminal repeat sequence. Further analysis using restriction fragment length polymorphism in 192 patients with HAM/ TSP and 200 HCs revealed a higher incidence of 1 tax subgroup (taxA) in HAM/ TSP. taxA was present in 30 (15.5%) of 192 patients with HAM/ TSP and in 14 (7%) of 200 HCs. The difference was significant (chi2=6.47; P=.014; odds ratio, 2.46; 95% confidence interval, 1.26-4.80). This effect was independent of HLA-A*02, which has been reported to prevent HAM/ TSP development. These findings suggest that both host genetic factors and HTLV-I subgroup are associated with different risks for development of HAM/ TSP.[1]


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