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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, pX

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Disease relevance of Genes, pX


High impact information on Genes, pX

  • We examined the effect of the human T lymphotropic virus type 1 (HTLV-I) Tax gene product on the human transforming growth factor beta 1 (TGF-beta 1) promoter [6].
  • The ligand (muOX40L) is a type II membrane protein with significant identity to human gp34 (gp34), a protein whose expression on HTLV-1-infected human leukemic T cells is regulated by the tax gene [7].
  • However, in either EL-4 (T) cells or S194 cells, both lower-affinity sites can be significantly induced by the tax gene product of human T-cell leukemia virus type I, showing that NF-kappa B activity can be modulated even in a B-cell line that constitutively expresses this factor [8].
  • To explore whether there is genetic variation in HTLV-I tax that can escape CTL recognition during the development of ATL, the HTLV-I tax gene was sequenced in 55 patients with ATL, 61 patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and 62 healthy carriers, and it was correlated with the presence of HLA-A*02 [9].
  • The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells [10].

Chemical compound and disease context of Genes, pX


Biological context of Genes, pX


Anatomical context of Genes, pX


Gene context of Genes, pX

  • These results suggest that the HTLV-I tax gene may transactivate the IL-8 gene through the kappa B site in HTLV-I-infected cells and that constitutive expression of the IL-8 gene may play a role in HTLV-I-associated pathogenesis [20].
  • Characterization of the loricrin (LOR) gene as a positional candidate for the PSORS4 psoriasis susceptibility locus [15].
  • trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human T-lymphotropic virus type 1 tax gene [21].
  • Furthermore, the tax gene strongly transactivated IL-6 gene promoter activity assayed by CAT assay [22].
  • These in vivo findings are consistent with other reports which have demonstrated in vitro cis-regulatory elements within the 5'-flanking regions of the genes for GM-CSF and the IL-2 receptor which are responsive to trans activation by the tax gene [21].

Analytical, diagnostic and therapeutic context of Genes, pX


  1. Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be trans-activated by HTLV-1 tax gene. Watanabe, T., Yamaguchi, K., Takatsuki, K., Osame, M., Yoshida, M. J. Exp. Med. (1990) [Pubmed]
  2. Rat cytotoxic T lymphocytes against human T-lymphotropic virus type 1-infected cells recognize gag gene and env gene encoded antigens. Noguchi, Y., Tateno, M., Kondo, N., Yoshiki, T., Shida, H., Nakayama, E., Shiku, H. J. Immunol. (1989) [Pubmed]
  3. Activation of the GM-CSF promoter by HTLV-I and -II tax proteins. Nimer, S.D., Gasson, J.C., Hu, K., Smalberg, I., Williams, J.L., Chen, I.S., Rosenblatt, J.D. Oncogene (1989) [Pubmed]
  4. Brain tumours and lymphomas in transgenic mice that carry HTLV-I LTR/c-myc and Ig/tax genes. Benvenisty, N., Ornitz, D.M., Bennett, G.L., Sahagan, B.G., Kuo, A., Cardiff, R.D., Leder, P. Oncogene (1992) [Pubmed]
  5. Anomalous behavior of bacteriophage lambda polypeptides in polyacrylamide gels: resolution, identification, and control of the lambda rex gene product. Belfort, M. J. Virol. (1978) [Pubmed]
  6. Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia. Kim, S.J., Kehrl, J.H., Burton, J., Tendler, C.L., Jeang, K.T., Danielpour, D., Thevenin, C., Kim, K.Y., Sporn, M.B., Roberts, A.B. J. Exp. Med. (1990) [Pubmed]
  7. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. Baum, P.R., Gayle, R.B., Ramsdell, F., Srinivasan, S., Sorensen, R.A., Watson, M.L., Seldin, M.F., Baker, E., Sutherland, G.R., Clifford, K.N. EMBO J. (1994) [Pubmed]
  8. Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene. Mauxion, F., Jamieson, C., Yoshida, M., Arai, K., Sen, R. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  9. Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia. Furukawa, Y., Kubota, R., Tara, M., Izumo, S., Osame, M. Blood (2001) [Pubmed]
  10. The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Pozzatti, R., Vogel, J., Jay, G. Mol. Cell. Biol. (1990) [Pubmed]
  11. Role of protein kinase A in tax transactivation of the human T-cell leukemia virus type I long terminal repeat. Kadison, P., Poteat, H.T., Klein, K.M., Faller, D.V. J. Virol. (1990) [Pubmed]
  12. The rex genes of lambda prophage modify ultraviolet light and N-methyl-N-nitrosourea-induced responses to DNA damage in Escherichia coli. Fix, D. Mutat. Res. (1993) [Pubmed]
  13. The human T cell leukemia virus type I-tax gene is responsible for the development of both inflammatory polyarthropathy resembling rheumatoid arthritis and noninflammatory ankylotic arthropathy in transgenic mice. Habu, K., Nakayama-Yamada, J., Asano, M., Saijo, S., Itagaki, K., Horai, R., Yamamoto, H., Sekiguchi, T., Nosaka, T., Hatanaka, M., Iwakura, Y. J. Immunol. (1999) [Pubmed]
  14. A sequence homology between the pX genes of HTLV-I/II and the murine IL-3 gene. Gojobori, T., Aota, S., Inoue, T., Shimotohno, K. FEBS Lett. (1986) [Pubmed]
  15. Characterization of the loricrin (LOR) gene as a positional candidate for the PSORS4 psoriasis susceptibility locus. Giardina, E., Capon, F., De Rosa, M.C., Mango, R., Zambruno, G., Orecchia, A., Chimenti, S., Giardina, B., Novelli, G. Ann. Hum. Genet. (2004) [Pubmed]
  16. Nucleotide sequence analysis of isolates of human T-lymphotropic virus type 1 of diverse geographical origins. Ratner, L., Philpott, T., Trowbridge, D.B. AIDS Res. Hum. Retroviruses (1991) [Pubmed]
  17. A mechanism of apoptosis induced by all-trans retinoic acid on adult T-cell leukemia cells: a possible involvement of the Tax/NF-kappaB signaling pathway. Nawata, H., Maeda, Y., Sumimoto, Y., Miyatake, J., Kanamaru, A. Leuk. Res. (2001) [Pubmed]
  18. A novel animal model of thymic tumour: development of epithelial thymoma in transgenic rats carrying human T lymphocyte virus type I pX gene. Kikuchi, K., Ikeda, H., Tsuchikawa, T., Tsuji, T., Tanaka, S., Fugo, K., Sugaya, T., Tanaka, Y., Tateno, M., Maruyama, N., Yoshiki, T. International journal of experimental pathology. (2002) [Pubmed]
  19. Tumor necrosis factor-alpha and interferon-gamma, but not HTLV-I tax, are likely factors in the epidermotropism of cutaneous T-cell lymphoma via induction of interferon-inducible protein-10. Daliani, D., Ulmer, R.A., Jackow, C., Pugh, W., Gansbacher, B., Cabanillas, F., Duvic, M., Sarris, A.H. Leuk. Lymphoma (1998) [Pubmed]
  20. Production of interleukin 8 in adult T-cell leukemia cells: possible transactivation of the interleukin 8 gene by human T-cell leukemia virus type I tax. Mori, N., Murakami, S., Oda, S., Prager, D., Eto, S. Cancer Res. (1995) [Pubmed]
  21. trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human T-lymphotropic virus type 1 tax gene. Green, J.E., Begley, C.G., Wagner, D.K., Waldmann, T.A., Jay, G. Mol. Cell. Biol. (1989) [Pubmed]
  22. Human T-cell leukemia virus type I tax transactivates the interleukin-6 gene in human rheumatoid synovial cells. Mori, N., Shirakawa, F., Abe, M., Kamo, Y., Koyama, Y., Murakami, S., Shimizu, H., Yamamoto, K., Oda, S., Eto, S. J. Rheumatol. (1995) [Pubmed]
  23. Immunoelectron microscopic localization of the pX gene products in human T-cell leukemia virus type 1-producing cells. Oda, T., Watanabe, S., Sumii, H., Nakamura, T., Arakaki, Y., Shimotohno, K. Cancer Res. (1987) [Pubmed]
  24. Isolation of virus-producing transformants from human gastric cancer cell line, HGC-27, infected with human T-cell leukemia virus type I. Akagi, T., Yoshino, T., Motoi, M., Takata, H., Yano, S., Miyoshi, I., Oka, T., Ohtsuki, Y. Jpn. J. Cancer Res. (1988) [Pubmed]
  25. Detection of HTLV-I pX gene by polymerase chain reaction using newly designed primers. Imajo, K., Shinagawa, K., Tada, S., Tsubota, T., Kimura, I. Acta Med. Okayama (1993) [Pubmed]
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