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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Radiation exposure does not alter metallothionein III isoform expression in mouse brain.

The level of metallothionein III mRNA and protein, a brain-specific isoform of metallothionein (MT), was investigated in the brain of MT-I and -II gene knockout (MT-null) mice exposed to 20 Gy whole-body gamma-irradiation. Because MT-null mice did not express MT-I or MT-II isoforms, the total brain MT content in these mice represented the isoform MT-III only. MT-III protein content was determined by a cadmium-binding assay, and the MT mRNA level was measured by reverse transcription followed by polymerase chain reaction (RT-PCR). Both MT-III protein content and mRNA expression in the brains of MT-null mice were not affected by exposure to whole-body irradiation. These results indicate that mouse brain MT-III expression is not induced by ionizing radiation.[1]

References

  1. Radiation exposure does not alter metallothionein III isoform expression in mouse brain. Ono, S.I., Cai, L., Koropatnick, J., Cherian, M.G. Biological trace element research. (2000) [Pubmed]
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