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Brennan, S. et al.

Brennan, Cooper, Sly,

Directed neutrophil migration to IL-8 is increased in cystic fibrosis: a study of the effect of erythromycin.

BACKGROUND: The aim of this study was to compare neutrophil migration in cystic fibrosis ( CF) and non- CF populations and to investigate the effect of erythromycin on directed migration of neutrophils (PMNs) in CF. METHODS: PMNs were isolated and their migratory capacity in response to interleukin-8 (IL-8) or f-Met-Leu-Phe (fMLP) in the presence or absence of erythromycin (1-100 microg/ml) was assessed. RESULTS: CF derived PMNs showed significantly increased migration to IL-8 but not to fMLP compared with non- CF PMNs. Erythromycin had no significant effect on migration responses to IL-8 and in vitro exposure of PMNs to erythromycin had no effect. CONCLUSIONS: CF derived PMNs show higher migratory responsiveness to IL-8 but not to fMLP, suggesting that CF PMNs may be "primed" to IL-8 which is significantly increased in CF serum compared with non- CF serum. Treatment with erythromycin had no significant effect on PMN migration in vitro.[1]

References

Directed neutrophil migration to IL-8 is increased in cystic fibrosis: a study of the effect of erythromycin. Brennan, S., Cooper, D., Sly, P.D. Thorax (2001) [Pubmed]

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