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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

NM  -  neutrophil migration

Homo sapiens

Synonyms: GP130, NCR
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Disease relevance of NM


Psychiatry related information on NM


High impact information on NM


Chemical compound and disease context of NM


Biological context of NM

  • The results suggested that the decreased expression of GP130 in ejaculated spermatozoa could be associated with low sperm motility in asthenozoospermic men [18].
  • The inability of IL-12(-/-) mice to restrict the infection was not due to impairment of neutrophil migration, but correlated with decrease of phagocytosis, NO production, and microbicidal activities of their neutrophils, and with reduction of systemic IFN-gamma synthesis [1].
  • A statistically significant association of low HG (1 and 2) was found with DI of more than 1 (hyperdiploid), single copy of NM gene per haploid genome, and an LDH of less than 1500 IU/l (P value for each, < 0.001), factors that are associated with better prognosis [5].
  • Neutrophil migration inhibitory properties of polyunsaturated fatty acids. The role of fatty acid structure, metabolism, and possible second messenger systems [19].
  • Structural analysis of human neutrophil migration. Centriole, microtubule, and microfilament orientation and function during chemotaxis [20].

Anatomical context of NM


Associations of NM with chemical compounds


Physical interactions of NM

  • No evidence of neutrophil migration was observed towards purified complex derived from equine neutrophil elastase and the Spi 1 isoform of equine API, or to crude mixtures of porcine pancreatic elastase and unseparated equine API isoforms, although the same neutrophil preparations actively migrated towards zymosan activated plasma [30].
  • Sera obtained from patients with rheumatoid arthritis with evidence of circulating immune complexes were able to significantly inhibit neutrophil migration, indicating that this phenomenon may be a useful means for the detection of circulating immune complexes [31].
  • The results also suggest that neutrophil migration induced by KM+ involves binding to CXCR2 [32].

Enzymatic interactions of NM


Regulatory relationships of NM


Other interactions of NM

  • A-1-AT concentrations in the NM group were lower than in the BM group (P = 0.0002) and the TBM group (P = 0.0005) but did not differ from the concentrations in VM; those in the VM group were lower than in the BM group (P = 0.0001) and the TBM group (P = 0.003) but no difference was found between the BM and TBM groups [4].
  • Further analysis showed that this antibody recognized CD47, a ubiquitously expressed plasma membrane protein previously implicated in integrin function, host defense action, and neutrophil migration [39].
  • We recently reported that heme is a proinflammatory molecule, able to induce neutrophil migration, reactive oxygen species generation, and IL-8 expression [40].
  • TNF-alpha, a proinflammatory cytokine, initiates expression of endothelial cell surface adhesion molecules and neutrophil migration. p38, a member of the mitogen-activated protein kinases, plays an important role in mediating intracellular signal transduction in endotoxin-induced inflammatory responses [35].
  • Supernatants of the VEGF/VPF-treated HBMECs significantly increased neutrophil migration across the HBMEC monolayer compared with those of the untreated control [41].

Analytical, diagnostic and therapeutic context of NM


  1. IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. Moreno, S.E., Alves-Filho, J.C., Alfaya, T.M., da Silva, J.S., Ferreira, S.H., Liew, F.Y. J. Immunol. (2006) [Pubmed]
  2. Endotoxemia enhances expression of the signaling receptor (GP130) on protein and molecular level. Marsik, C., Halama, T., Cardona, F., Schlifke, I., Mittermayer, F., Jilma, B. Clin. Immunol. (2005) [Pubmed]
  3. Multiple myeloma and B cell lymphoma. Investigation of IL-6, IL-6 receptor antagonist (IL-6RA), and GP130 antagonist (GP130A) using various parameters in an in vitro model. Kovacs, E. ScientificWorldJournal (2006) [Pubmed]
  4. Cerebrospinal fluid alpha-1-antitrypsin alpha-1-antitrypsin-elastase complex levels in meningitis. Hoffman, H.D., Donald, P.R., Hanekom, C., De Beer, F.C. Eur. J. Clin. Invest. (1989) [Pubmed]
  5. Correlation between morphologic and other prognostic markers of neuroblastoma. A study of histologic grade, DNA index, N-myc gene copy number, and lactic dehydrogenase in patients in the Pediatric Oncology Group. Joshi, V.V., Cantor, A.B., Brodeur, G.M., Look, A.T., Shuster, J.J., Altshuler, G., Larkin, E.W., Holbrook, C.T., Silverman, J.F., Norris, H.T. Cancer (1993) [Pubmed]
  6. Nitric oxide: biphasic dose responses. Calabrese, E.J. Crit. Rev. Toxicol. (2001) [Pubmed]
  7. Modulation of nonspecific host defenses in fish. Fletcher, T.C. Vet. Immunol. Immunopathol. (1986) [Pubmed]
  8. Annexins: from structure to function. Gerke, V., Moss, S.E. Physiol. Rev. (2002) [Pubmed]
  9. Treatment of cyclic neutropenia with granulocyte colony-stimulating factor. Hammond, W.P., Price, T.H., Souza, L.M., Dale, D.C. N. Engl. J. Med. (1989) [Pubmed]
  10. Effect of lithium on neutrophil mass and production. Rothstein, G., Clarkson, D.R., Larsen, W., Grosser, B.I., Athens, J.W. N. Engl. J. Med. (1978) [Pubmed]
  11. Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin. Hendey, B., Klee, C.B., Maxfield, F.R. Science (1992) [Pubmed]
  12. Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Huber, A.R., Kunkel, S.L., Todd, R.F., Weiss, S.J. Science (1991) [Pubmed]
  13. CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge. Lekstrom-Himes, J., Xanthopoulos, K.G. Blood (1999) [Pubmed]
  14. Intracellular and cell surface localization of a complex between alphaMbeta2 integrin and promatrix metalloproteinase-9 progelatinase in neutrophils. Stefanidakis, M., Ruohtula, T., Borregaard, N., Gahmberg, C.G., Koivunen, E. J. Immunol. (2004) [Pubmed]
  15. Directed neutrophil migration to IL-8 is increased in cystic fibrosis: a study of the effect of erythromycin. Brennan, S., Cooper, D., Sly, P.D. Thorax (2001) [Pubmed]
  16. Effect of ibuprofen on neutrophil migration in vivo in cystic fibrosis and healthy subjects. Konstan, M.W., Krenicky, J.E., Finney, M.R., Kirchner, H.L., Hilliard, K.A., Hilliard, J.B., Davis, P.B., Hoppel, C.L. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  17. Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis. Bezerra, M.M., Brain, S.D., Gir??o, V.C., Greenacre, S., Keeble, J., Rocha, F.A. Naunyn Schmiedebergs Arch. Pharmacol. (2007) [Pubmed]
  18. Low expression of glycoprotein subunit 130 in ejaculated spermatozoa from asthenozoospermic men. Cai, Z.M., Gui, Y.T., Guo, X., Yu, J., Guo, L.D., Zhang, L.B., Wang, H., Yu, J. J. Androl. (2006) [Pubmed]
  19. Neutrophil migration inhibitory properties of polyunsaturated fatty acids. The role of fatty acid structure, metabolism, and possible second messenger systems. Ferrante, A., Goh, D., Harvey, D.P., Robinson, B.S., Hii, C.S., Bates, E.J., Hardy, S.J., Johnson, D.W., Poulos, A. J. Clin. Invest. (1994) [Pubmed]
  20. Structural analysis of human neutrophil migration. Centriole, microtubule, and microfilament orientation and function during chemotaxis. Malech, H.L., Root, R.K., Gallin, J.I. J. Cell Biol. (1977) [Pubmed]
  21. EphB2 regulates axonal growth at the midline in the developing auditory brainstem. Cramer, K.S., Cerretti, D.P., Siddiqui, S.A. Dev. Biol. (2006) [Pubmed]
  22. Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils. Gasson, J.C., Weisbart, R.H., Kaufman, S.E., Clark, S.C., Hewick, R.M., Wong, G.G., Golde, D.W. Science (1984) [Pubmed]
  23. Antiadhesive role of apical decay-accelerating factor (CD55) in human neutrophil transmigration across mucosal epithelia. Lawrence, D.W., Bruyninckx, W.J., Louis, N.A., Lublin, D.M., Stahl, G.L., Parkos, C.A., Colgan, S.P. J. Exp. Med. (2003) [Pubmed]
  24. Long-term impaired neutrophil migration in mice overexpressing human interleukin-8. Simonet, W.S., Hughes, T.M., Nguyen, H.Q., Trebasky, L.D., Danilenko, D.M., Medlock, E.S. J. Clin. Invest. (1994) [Pubmed]
  25. Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl-phenylalanine. Loike, J.D., el Khoury, J., Cao, L., Richards, C.P., Rascoff, H., Mandeville, J.T., Maxfield, F.R., Silverstein, S.C. J. Exp. Med. (1995) [Pubmed]
  26. The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1. Taooka, Y., Chen, J., Yednock, T., Sheppard, D. J. Cell Biol. (1999) [Pubmed]
  27. Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8. Kuijpers, T.W., Hakkert, B.C., Hart, M.H., Roos, D. J. Cell Biol. (1992) [Pubmed]
  28. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Mrsny, R.J., Gewirtz, A.T., Siccardi, D., Savidge, T., Hurley, B.P., Madara, J.L., McCormick, B.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  29. Effects of human neutrophil elastase (HNE) on neutrophil function in vitro and in inflamed microvessels. Woodman, R.C., Reinhardt, P.H., Kanwar, S., Johnston, F.L., Kubes, P. Blood (1993) [Pubmed]
  30. Neutrophil chemotaxis in the horse is not mediated by a complex of equine neutrophil elastase and equine alpha-1-proteinase inhibitor. Scudamore, C.L., Pemberton, A., Watson, E.D., Miller, H.R. Br. Vet. J. (1993) [Pubmed]
  31. Inhibition of human neutrophil migration by aggregated gammaglobulin. Kemp, A., Roberts-Thomson, P., Brown, S. Clin. Exp. Immunol. (1979) [Pubmed]
  32. Neutrophil activation induced by the lectin KM+ involves binding to CXCR2. Pereira-da-Silva, G., Moreno, A.N., Marques, F., Oliver, C., Célia Jamur, M., Panunto-Castelo, A., Roque-Barreira, M.C. Biochim. Biophys. Acta (2006) [Pubmed]
  33. Role of interleukin-8 phosphorylated kinases in stimulating neutrophil migration through fibrin gels. Schnyder, B., Bogdan, J.A., Schnyder-Candrian, S. Lab. Invest. (1999) [Pubmed]
  34. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. White, J.R., Lee, J.M., Young, P.R., Hertzberg, R.P., Jurewicz, A.J., Chaikin, M.A., Widdowson, K., Foley, J.J., Martin, L.D., Griswold, D.E., Sarau, H.M. J. Biol. Chem. (1998) [Pubmed]
  35. Alcohol (ethanol) inhibits IL-8 and TNF: role of the p38 pathway. Arbabi, S., Garcia, I., Bauer, G.J., Maier, R.V. J. Immunol. (1999) [Pubmed]
  36. The role of granulocyte-macrophage and granulocyte colony-stimulating factors in neutrophil transendothelial migration: comparison with interleukin-8. Smith, W.B., Gamble, J.R., Vadas, M.A. Exp. Hematol. (1994) [Pubmed]
  37. Interleukin-13 is a monocyte chemoattractant. Magazin, M., Guillemot, J.C., Vita, N., Ferrara, P. Eur. Cytokine Netw. (1994) [Pubmed]
  38. IL-8 secretion and neutrophil activation by HT-29 colonic epithelial cells. Kelly, C.P., Keates, S., Siegenberg, D., Linevsky, J.K., Pothoulakis, C., Brady, H.R. Am. J. Physiol. (1994) [Pubmed]
  39. Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47. Seiffert, M., Cant, C., Chen, Z., Rappold, I., Brugger, W., Kanz, L., Brown, E.J., Ullrich, A., Bühring, H.J. Blood (1999) [Pubmed]
  40. Heme inhibits human neutrophil apoptosis: involvement of phosphoinositide 3-kinase, MAPK, and NF-kappaB. Arruda, M.A., Rossi, A.G., de Freitas, M.S., Barja-Fidalgo, C., Graça-Souza, A.V. J. Immunol. (2004) [Pubmed]
  41. Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells. Lee, T.H., Avraham, H., Lee, S.H., Avraham, S. J. Biol. Chem. (2002) [Pubmed]
  42. Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Lefer, A.M., Lefer, D.J. Annu. Rev. Pharmacol. Toxicol. (1993) [Pubmed]
  43. Neutrophil migration is defective during recombinant human granulocyte-macrophage colony-stimulating factor infusion after autologous bone marrow transplantation in humans. Peters, W.P., Stuart, A., Affronti, M.L., Kim, C.S., Coleman, R.E. Blood (1988) [Pubmed]
  44. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. Shi, Y., Ullrich, S.J., Zhang, J., Connolly, K., Grzegorzewski, K.J., Barber, M.C., Wang, W., Wathen, K., Hodge, V., Fisher, C.L., Olsen, H., Ruben, S.M., Knyazev, I., Cho, Y.H., Kao, V., Wilkinson, K.A., Carrell, J.A., Ebner, R. J. Biol. Chem. (2000) [Pubmed]
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