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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization.

In Drosophila syncytial blastoderm embryos, centrosomes specify the position of actin-based interphase caps and mitotic furrows. Mutations in the scrambled locus prevent assembly of mitotic furrows, but do not block actin cap formation. The scrambled gene encodes a protein that localizes to the mitotic furrows and centrosomes. Sced localization, actin reorganization from caps into mitotic furrows, and centrosome-coordinated assembly of actin caps are not blocked by microtubule disruption. Our results indicate that centrosomes may coordinate assembly of cortical actin caps through a microtubule-independent mechanism, and that Scrambled mediates a second microtubule-independent process that drives mitotic furrow assembly.[1]


  1. Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization. Stevenson, V.A., Kramer, J., Kuhn, J., Theurkauf, W.E. Nat. Cell Biol. (2001) [Pubmed]
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