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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Mutagenesis of the borage Delta(6) fatty acid desaturase.

The consensus sequence of the third histidine box of a range of Delta(5), Delta(6), Delta(8) and sphingolipid desaturases differs from that of the membrane-bound non-fusion Delta(12) and Delta(15) desaturases in the presence of glutamine instead of histidine. We have used site-directed mutagenesis to determine the importance of glutamine and other residues of the third histidine box and created a chimaeric enzyme to determine the ability of the Cyt b(5) fusion domain from the plant sphingolipid desaturase to substitute for the endogenous domain of the Delta(6) desaturase.[1]


  1. Mutagenesis of the borage Delta(6) fatty acid desaturase. Sayanova, O., Beaudoin, F., Libisch, B., Shewry, P., Napier, J. Biochem. Soc. Trans. (2000) [Pubmed]
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