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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Borago


High impact information on Borago

  • To enable the production of GLA in conventional oilseeds, we have isolated a cDNA encoding the delta6-fatty acid desaturase from developing seeds of borage and confirmed its function by expression in transgenic tobacco plants [6].
  • Diets were supplemented with several dosages of oils containing either gamma-linolenic acid (GLA) (borage oil), eicosapentaenoic acid (EPA) (sardine oil), or a combination of the two in a dose-response protocol [7].
  • We administered borage seed oil (9 capsules/day) for 12 weeks to 7 normal controls and to 7 patients with active rheumatoid arthritis [8].
  • Histidine-41 of the cytochrome b5 domain of the borage delta6 fatty acid desaturase is essential for enzyme activity [9].
  • The borage oil diet increased serum cholesterol levels in WKY rats and hepatic B-hydroxy-3-methylglutaryl coenzyme A reductase in SHR [10].

Biological context of Borago


Anatomical context of Borago


Associations of Borago with chemical compounds


Gene context of Borago

  • In addition, borage oil-, primrose oil- and fish-borage oil mixture-fed mice had significantly (P less than 0.05) higher levels of dihomo-gamma-linolenic acid [20:3(n-6)] in membrane phospholipids (5.5, 3.5 and 5.7 mol/100 mol, respectively) relative to corn oil-fed mice (2.0 mol/100 mol).(ABSTRACT TRUNCATED AT 250 WORDS)[17]
  • Interestingly, despite the lack of DGLA in SPH, this phospholipid exhibited a marked enrichment in nervonic acid (NA, 24:1n-9) from 16.2 to 24.7 mol% upon borage oil consumption [25].
  • Weanling GPs were initially fed diets supplemented with olive oil (less than 0.1% EPA; less than 0.1% GLA) for 2 weeks, followed by a crossover by two sets of animals to diets supplemented with fish oil (19% EPA) or borage oil (25% GLA) [26].
  • Effects of dietary gamma-linolenic acid-rich borage oil combined with marine fish oils on tissue phospholipid fatty acid composition and production of prostaglandins E and F of the 1-, 2- and 3-series in a marine fish deficient in delta5 fatty acyl desaturase [27].
  • The rapid evaluation of antioxidant activity of crude borage (Borago officinalis L.) extract was determined by using DPPH free radical method [28].

Analytical, diagnostic and therapeutic context of Borago


  1. Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. Engler, M.M., Schambelan, M., Engler, M.B., Ball, D.L., Goodfriend, T.L. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  2. Effect of short-term enteral feeding with eicosapentaenoic and gamma-linolenic acids on alveolar macrophage eicosanoid synthesis and bactericidal function in rats. Palombo, J.D., DeMichele, S.J., Boyce, P.J., Lydon, E.E., Liu, J.W., Huang, Y.S., Forse, R.A., Mizgerd, J.P., Bistrian, B.R. Crit. Care Med. (1999) [Pubmed]
  3. Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Henz, B.M., Jablonska, S., van de Kerkhof, P.C., Stingl, G., Blaszczyk, M., Vandervalk, P.G., Veenhuizen, R., Muggli, R., Raederstorff, D. Br. J. Dermatol. (1999) [Pubmed]
  4. Effect of administration of gamma-linolenic acid on the fatty acid composition of serum phospholipids and cholesteryl esters in patients with cystic fibrosis. Christophe, A., Robberecht, E., Franckx, H., De Baets, F., van de Pas, M. Ann. Nutr. Metab. (1994) [Pubmed]
  5. Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. Karia, C., Harwood, J.L., Morris, A.P., Heard, C.M. International journal of pharmaceutics. (2004) [Pubmed]
  6. Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of high levels of delta6-desaturated fatty acids in transgenic tobacco. Sayanova, O., Smith, M.A., Lapinskas, P., Stobart, A.K., Dobson, G., Christie, W.W., Shewry, P.R., Napier, J.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Effects of altering the eicosanoid precursor pool on neovascularization and inflammation in the alkali-burned rabbit cornea. Ormerod, L.D., Garsd, A., Abelson, M.B., Kenyon, K.R. Am. J. Pathol. (1990) [Pubmed]
  8. Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma-linolenic acid. Pullman-Mooar, S., Laposata, M., Lem, D., Holman, R.T., Leventhal, L.J., DeMarco, D., Zurier, R.B. Arthritis Rheum. (1990) [Pubmed]
  9. Histidine-41 of the cytochrome b5 domain of the borage delta6 fatty acid desaturase is essential for enzyme activity. Sayanova, O., Shewry, P.R., Napier, J.A. Plant Physiol. (1999) [Pubmed]
  10. Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. Engler, M.M., Engler, M.B., Erickson, S.K., Paul, S.M. J. Hypertens. (1992) [Pubmed]
  11. Chimeras of Delta6-fatty acid and Delta8-sphingolipid desaturases. Libisch, B., Michaelson, L.V., Lewis, M.J., Shewry, P.R., Napier, J.A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  12. Genotypic variation in fatty acid content of blackcurrant seeds. Ruiz del Castillo, M.L., Dobson, G., Brennan, R., Gordon, S. J. Agric. Food Chem. (2002) [Pubmed]
  13. Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats. Engler, M.M., Engler, M.B. Prostaglandins Leukot. Essent. Fatty Acids (1998) [Pubmed]
  14. Mutagenesis of the borage Delta(6) fatty acid desaturase. Sayanova, O., Beaudoin, F., Libisch, B., Shewry, P., Napier, J. Biochem. Soc. Trans. (2000) [Pubmed]
  15. Alteration of baroreflex control of forearm vascular resistance by dietary fatty acids. Mills, D.E., Mah, M., Ward, R.P., Morris, B.L., Floras, J.S. Am. J. Physiol. (1990) [Pubmed]
  16. Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. Mancuso, P., Whelan, J., DeMichele, S.J., Snider, C.C., Guszcza, J.A., Claycombe, K.J., Smith, G.T., Gregory, T.J., Karlstad, M.D. Crit. Care Med. (1997) [Pubmed]
  17. Mouse peritoneal macrophage prostaglandin E1 synthesis is altered by dietary gamma-linolenic acid. Fan, Y.Y., Chapkin, R.S. J. Nutr. (1992) [Pubmed]
  18. Comparative effects of alpha- and gamma-linolenic acids on rat liver fatty acid oxidation. Kumamoto, T., Ide, T. Lipids (1998) [Pubmed]
  19. Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. Tocher, D.R., Bell, J.G., Dick, J.R., Sargent, J.R. Lipids (1997) [Pubmed]
  20. Essential fatty acids alter the activity of manganese-superoxide dismutase in rat heart. Phylactos, A.C., Harbige, L.S., Crawford, M.A. Lipids (1994) [Pubmed]
  21. Biosynthesis of gamma-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis). Stymne, S., Stobart, A.K. Biochem. J. (1986) [Pubmed]
  22. Dietary supplementation with ethyl ester concentrates of fish oil (n-3) and borage oil (n-6) polyunsaturated fatty acids induces epidermal generation of local putative anti-inflammatory metabolites. Miller, C.C., Tang, W., Ziboh, V.A., Fletcher, M.P. J. Invest. Dermatol. (1991) [Pubmed]
  23. Delta 6- and delta 12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis). Griffiths, G., Stobart, A.K., Stymne, S. Biochem. J. (1988) [Pubmed]
  24. Dietary fish oil and fish and borage oil suppress intrapulmonary proinflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats. Mancuso, P., Whelan, J., DeMichele, S.J., Snider, C.C., Guszcza, J.A., Karlstad, M.D. Crit. Care Med. (1997) [Pubmed]
  25. The effect of borage oil consumption on the composition of individual phospholipids in human platelets. Barre, D.E., Holub, B.J. Lipids (1992) [Pubmed]
  26. Effects of dietary supplementation with eicosapentaenoic acid or gamma-linolenic acid on neutrophil phospholipid fatty acid composition and activation responses. Fletcher, M.P., Ziboh, V.A. Inflammation (1990) [Pubmed]
  27. Effects of dietary gamma-linolenic acid-rich borage oil combined with marine fish oils on tissue phospholipid fatty acid composition and production of prostaglandins E and F of the 1-, 2- and 3-series in a marine fish deficient in delta5 fatty acyl desaturase. Tocher, D.R., Bell, J.G., Farndale, B.M., Sargent, J.R. Prostaglandins Leukot. Essent. Fatty Acids (1997) [Pubmed]
  28. The detection of radical scavenging compounds in crude extract of borage (Borago officinalis L.) by using an on-line HPLC-DPPH method. Bandoniene, D., Murkovic, M. J. Biochem. Biophys. Methods (2002) [Pubmed]
  29. Mutagenesis and heterologous expression in yeast of a plant Delta6-fatty acid desaturase. Sayanova, O., Beaudoin, F., Libisch, B., Castel, A., Shewry, P.R., Napier, J.A. J. Exp. Bot. (2001) [Pubmed]
  30. Determination of rosmarinic acid in sage and borage leaves by high-performance liquid chromatography with different detection methods. Bandoniene, D., Murkovic, M., Venskutonis, P.R. Journal of chromatographic science. (2005) [Pubmed]
  31. Dietary gamma-linolenic acid in the form of borage oil causes less body fat accumulation accompanying an increase in uncoupling protein 1 mRNA level in brown adipose tissue. Takahashi, Y., Ide, T., Fujita, H. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2000) [Pubmed]
  32. Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha. Kast, R.E. Int. Immunopharmacol. (2001) [Pubmed]
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