- The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK. Meadows, H.J., Chapman, C.G., Duckworth, D.M., Kelsell, R.E., Murdock, P.R., Nasir, S., Rennie, G., Randall, A.D. Brain Res. (2001)