Gene Review:
Kcnk2 - potassium channel, subfamily K, member 2
Mus musculus
Synonyms:
A430027H14Rik, AI848635, Outward rectifying potassium channel protein TREK-1, Potassium channel subfamily K member 2, TREK-1, ...
- TREK-1, a K+ channel involved in neuroprotection and general anesthesia. Heurteaux, C., Guy, N., Laigle, C., Blondeau, N., Duprat, F., Mazzuca, M., Lang-Lazdunski, L., Widmann, C., Zanzouri, M., Romey, G., Lazdunski, M. EMBO J. (2004)
- A phospholipid sensor controls mechanogating of the K+ channel TREK-1. Chemin, J., Patel, A.J., Duprat, F., Lauritzen, I., Lazdunski, M., Honoré, E. EMBO J. (2005)
- Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat. Nicolas, M.T., Lesage, F., Reyes, R., Barhanin, J., Demêmes, D. Brain Res. (2004)
- AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels. Sandoz, G., Th??mmler, S., Duprat, F., Feliciangeli, S., Vinh, J., Escoubas, P., Guy, N., Lazdunski, M., Lesage, F. EMBO J. (2006)
- TREK-1, a K+ channel involved in polymodal pain perception. Alloui, A., Zimmermann, K., Mamet, J., Duprat, F., Noël, J., Chemin, J., Guy, N., Blondeau, N., Voilley, N., Rubat-Coudert, C., Borsotto, M., Romey, G., Heurteaux, C., Reeh, P., Eschalier, A., Lazdunski, M. EMBO J. (2006)
- Cloning and functional expression of a novel cardiac two-pore background K+ channel (cTBAK-1). Kim, D., Fujita, A., Horio, Y., Kurachi, Y. Circ. Res. (1998)
- Antipsychotics inhibit TREK but not TRAAK channels. Thümmler, S., Duprat, F., Lazdunski, M. Biochem. Biophys. Res. Commun. (2007)
- TREK-1 is a heat-activated background K(+) channel. Maingret, F., Lauritzen, I., Patel, A.J., Heurteaux, C., Reyes, R., Lesage, F., Lazdunski, M., Honoré, E. EMBO J. (2000)
- A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids. Fink, M., Lesage, F., Duprat, F., Heurteaux, C., Reyes, R., Fosset, M., Lazdunski, M. EMBO J. (1998)
- TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. An essential role in smooth muscle inhibitory neurotransmission. Koh, S.D., Monaghan, K., Sergeant, G.P., Ro, S., Walker, R.L., Sanders, K.M., Horowitz, B. J. Biol. Chem. (2001)
- Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton. Lauritzen, I., Chemin, J., Honoré, E., Jodar, M., Guy, N., Lazdunski, M., Jane Patel, A. EMBO Rep. (2005)
- Polyunsaturated fatty acids are potent neuroprotectors. Lauritzen, I., Blondeau, N., Heurteaux, C., Widmann, C., Romey, G., Lazdunski, M. EMBO J. (2000)
- An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1. Honoré, E., Maingret, F., Lazdunski, M., Patel, A.J. EMBO J. (2002)
- Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds. Richter, T.A., Dvoryanchikov, G.A., Chaudhari, N., Roper, S.D. J. Neurophysiol. (2004)
- Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype. Heurteaux, C., Lucas, G., Guy, N., El Yacoubi, M., Thümmler, S., Peng, X.D., Noble, F., Blondeau, N., Widmann, C., Borsotto, M., Gobbi, G., Vaugeois, J.M., Debonnel, G., Lazdunski, M. Nat. Neurosci. (2006)
- Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link. Garry, A., Fromy, B., Blondeau, N., Henrion, D., Brau, F., Gounon, P., Guy, N., Heurteaux, C., Lazdunski, M., Saumet, J.L. EMBO Rep. (2007)
- Simultaneous activation of p38 MAPK and p42/44 MAPK by ATP stimulates the K+ current ITREK in cardiomyocytes. Aimond, F., Rauzier, J.M., Bony, C., Vassort, G. J. Biol. Chem. (2000)