Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.
The Drosophila Dmblm locus is a homolog of the human Bloom syndrome gene, which encodes a helicase of the RECQ family. We show that Dmblm is identical to mus309, a locus originally identified in a mutagen-sensitivity screen. One mus309 allele, which carries a stop codon between two of the helicase motifs, causes partial male sterility and complete female sterility. Mutant males produce an excess of XY sperm and nullo sperm, consistent with a high frequency of nondisjunction and/or chromosome loss. These phenotypes of mus309 suggest that Dmblm functions in DNA double-strand break repair. The mutant Dmblm phenotypes were partially rescued by an extra copy of the DNA repair gene Ku70, indicating that the two genes functionally interact in vivo.[1]References
- Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70. Kusano, K., Johnson-Schlitz, D.M., Engels, W.R. Science (2001) [Pubmed]
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