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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Role of Rab9 GTPase in facilitating receptor recruitment by TIP47.

Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolases from the Golgi to endosomes and then return to the Golgi complex. TIP47 recognizes the cytoplasmic domains of MPRs and is required for endosome-to-Golgi transport. Here we show that TIP47 also bound directly to the Rab9 guanosine triphosphatase (GTPase) in its active, GTP-bound conformation. Moreover, Rab9 increased the affinity of TIP47 for its cargo. A functional Rab9 binding site was required for TIP47 stimulation of MPR transport in vivo. Thus, a cytosolic cargo selection device may be selectively recruited onto a specific organelle, and vesicle budding might be coupled to the presence of an active Rab GTPase.[1]


  1. Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. Carroll, K.S., Hanna, J., Simon, I., Krise, J., Barbero, P., Pfeffer, S.R. Science (2001) [Pubmed]
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