Chronic urticaria associated with intra-articular methylprednisolone.
Reports of allergic reactions following treatment with systemic corticosteroids are rare, despite their widespread use. A 47-year-old man developed widespread urticaria, resistant to antihistamines, coinciding with injections of local anaesthetic and methylprednisolone for cervical spondylosis. He underwent immediate and delayed hypersensitivity tests. Intradermal tests showed immediate-type sensitivity to methylprednisolone and hydrocortisone. Patch tests were positive to 21 of 26 corticosteroids tested. A diagnosis of both an immediate and a delayed-type hypersensitivity to corticosteroids was made. With avoidance of all corticosteroids he has been free from urticarial rash for 9 months and has been able to stop all medication.[1]References
- Chronic urticaria associated with intra-articular methylprednisolone. Pollock, B., Wilkinson, S.M., MacDonald Hull, S.P. Br. J. Dermatol. (2001) [Pubmed]
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